Lamotrigine (Epilepsy) updated on 04-22-2025

Oro-facial clefts

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17506
R73584		 Wiggs, 2024 Cleft lip and cleft palate early pregnancy population based cohort retrospective unexposed, sick Adjustment: Yes 1.71 [0.54;5.45] -/1,412   -/9,364 - 1,412
ref
S8119
R24943		 Holmes, 2008 All isolated (Cleft palate alone, Cleft lip alone and Cleft lip and palate) 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No 10.40 [4.30;24.90] 5/684   145/206,224 150 684
ref
Total 2 studies 4.39 [0.75;25.72] 150 2,096
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Wiggs, 2024Wiggs, 2024 1.71[0.54; 5.45]-1,41248%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Holmes, 2008Holmes, 2008 10.40[4.30; 24.90]15068452%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: moderateROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 83% 4.39[0.75; 25.72]1502,0960.550.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 4.39[0.75; 25.72]1502,09683%NAWiggs, 2024 Holmes, 2008 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 10.40[4.32; 25.03]150684 -NAHolmes, 2008 1 unexposed, sickunexposed, sick 1.71[0.54; 5.43]-1,412 -NAWiggs, 2024 1 Tags Adjustment   - No  - No 10.40[4.32; 25.03]150684 -NAHolmes, 2008 1   - Yes  - Yes 1.71[0.54; 5.43]-1,412 -NAWiggs, 2024 1 All studiesAll studies 4.39[0.75; 25.72]1502,09683%NAWiggs, 2024 Holmes, 2008 20.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale10.40[4.32; 25.03]150684 -NAHolmes, 2008 1 unexposed, sick controlsunexposed, sick controls 1.71[0.54; 5.43]-1,412 -NAWiggs, 2024 10.510.01.0