Lamotrigine (Epilepsy) updated on 04-22-2025

Extremely preterm (< 28 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S12612
R47534		 Van Marter (Controls unexposed, disease free), 2021 Prematurity - Extreme (<28 wk gestational age) at least 1st trimester prospective cohort unexposed, disease free excluded Adjustment: No 0.32 [0.01;7.90] C
excluded (control group) 		0/110   1/106 1 110
ref
S12614
R47546		 Van Marter (Controls unexposed, sick), 2021 Prematurity - Extreme (<28 wk gestational age) at least 1st trimester prospective cohort unexposed, sick Adjustment: No 0.13 [0.00;6.93] C 0/110   0/15 0 110
ref
Total 1 studies 0.13 [0.00;6.93] 0 110
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Van Marter (Controls unexposed, sick), 2021Van Marter, 2021 1 0.13[0.00; 6.93]01100%ROB confusion: criticalROB selection: lowROB classification: lowROB missing: lowROB mesure: moderateROB reporting: low0.02.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.13[0.00; 6.93]-110 -NAVan Marter (Controls unexposed, sick), 2021 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.13[0.00; 6.93]-110 -NAVan Marter (Controls unexposed, sick), 2021 1 Tags Adjustment   - No  - No 0.13[0.00; 6.93]-110 -NAVan Marter (Controls unexposed, sick), 2021 1 All studiesAll studies 0.13[0.00; 6.93]-110 -NAVan Marter (Controls unexposed, sick), 2021 10.010.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 12612

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale0.32[0.01; 7.90]1110 -NAVan Marter (Controls unexposed, disease free), 2021 1 unexposed, sick controlsunexposed, sick controls Out of scale0.13[0.00; 6.93]-110 -NAVan Marter (Controls unexposed, sick), 2021 10.510.01.0