Lamotrigine (Epilepsy) - Medication and Pregnancy KB

Lamotrigine (Epilepsy) updated on 04-22-2025

Low birth weight (< 2500g)

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S16017 R66490	Christensen (Lamotrigine) (Epilepsy), 2024	Low birth weight (<2500 g)	during pregnancy (anytime or not specified)	population based cohort retrospective	unexposed, sick	Adjustment: Yes	0.97 [0.83;1.13]	230/5,299 1,006/22,227	1,236	5,299		ref
S6394 R17470	Veiby (Controls unexposed, disease free) b, 2013	Low birth weight (< 2500 grams)	during pregnancy (anytime or not specified)	prospective cohort	unexposed, disease free excluded	Adjustment: Yes	1.20 [0.50;2.80] excluded (control group)	6/103 5,024/106,899	5,030	103		ref
S6393 R17451	Veiby (Controls unexposed, sick) b, 2013	Low birth weight (< 2500 grams)	during pregnancy (anytime or not specified)	prospective cohort	unexposed, sick	Adjustment: No	1.43 [0.55;3.75] ^C	6/103 16/386	22	103		ref
					Total	2 studies	0.98 [0.84;1.14]		1,258	5,402
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Lamotrigine) (Epilepsy; 2: Controls unexposed, sick) ;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 6394