Lamotrigine (Epilepsy)

Low birth weight (< 2500g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S5912
R14923		 Artama (Controls unexposed, disease free), 2013 Low birth weight (< 2500g) during pregnancy (anytime or not specified) population based cohort retrospective unexposed, disease free excluded Adjustment: Yes 0.99 [0.43;2.25]
excluded (control group) 		6/173   21,546/719,509 21,552 173
ref
S5920
R15019		 Artama (Controls unexposed, sick), 2013 Low birth weight (< 2500g) during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: Yes 0.96 [0.39;2.34] 6/173   65/1,793 71 173
ref
S6394
R17470		 Veiby (Controls unexposed, disease free) b, 2013 Low birth weight (< 2500 grams) during pregnancy (anytime or not specified) prospective cohort unexposed, disease free excluded Adjustment: Yes 1.20 [0.50;2.80]
excluded (control group) 		6/103   5,024/106,899 5,030 103
ref
S6393
R17451		 Veiby (Controls unexposed, sick) b, 2013 Low birth weight (< 2500 grams) during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No 1.43 [0.55;3.75] C 6/103   16/386 22 103
ref
Total 2 studies 1.15 [0.60;2.23] 93 276
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Artama (Controls unexposed, sick), 2013Artama, 2013 1 0.96[0.39; 2.34]7117354%ROB confusion: moderateROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Veiby (Controls unexposed, sick) b, 2013Veiby, 2013 2 1.43[0.55; 3.75]2210346%ROB confusion: unclearROB selection: lowROB classification: lowROB missing: moderateROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.15[0.60; 2.23]932760.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick; 2: Controls unexposed, sick) ;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.15[0.60; 2.23]932760%NAArtama (Controls unexposed, sick), 2013 Veiby (Controls unexposed, sick) b, 2013 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.15[0.60; 2.23]932760%NAArtama (Controls unexposed, sick), 2013 Veiby (Controls unexposed, sick) b, 2013 2 Tags Adjustment   - No  - No 1.43[0.55; 3.75]22103 -NAVeiby (Controls unexposed, sick) b, 2013 1   - Yes  - Yes 0.96[0.39; 2.35]71173 -NAArtama (Controls unexposed, sick), 2013 1 All studiesAll studies 1.15[0.60; 2.23]932760%NAArtama (Controls unexposed, sick), 2013 Veiby (Controls unexposed, sick) b, 2013 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 5912, 6394

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.09[0.60; 1.97]26,5822760%NAArtama (Controls unexposed, disease free), 2013 Veiby (Controls unexposed, disease free) b, 2013 2 unexposed, sick controlsunexposed, sick controls 1.15[0.60; 2.23]932760%NAArtama (Controls unexposed, sick), 2013 Veiby (Controls unexposed, sick) b, 2013 20.510.01.0