Oxcarbazepine (Epilepsy) updated on 04-22-2025

Caesarean

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S5927
R15097		 Artama (Oxcarbazepine) (Controls exposed to Lamotrigine, sick), 2013 Caesarean section during pregnancy (anytime or not specified) population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 1.01 [0.65;1.57] C
excluded (control group) 		99/532   32/173 131 532
ref
S5910
R14895		 Artama (Oxcarbazepine) (Controls unexposed, disease free), 2013 Caesarean section during pregnancy (anytime or not specified) population based cohort retrospective unexposed, disease free excluded Adjustment: Yes 1.21 [0.97;1.51]
excluded (control group) 		99/532   114,791/721,948 114,890 532
ref
S5918
R14991		 Artama (Oxcarbazepine) (Controls unexposed, sick), 2013 Caesarean section during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: Yes 0.98 [0.75;1.26] 99/532   331/1,800 430 532
ref
Total 1 studies 0.98 [0.76;1.27] 430 532
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Artama (Oxcarbazepine) (Controls unexposed, sick), 2013Artama, 2013 1 0.98[0.75; 1.26]4305320%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Oxcarbazepine) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.98[0.76; 1.27]430532 -NAArtama (Oxcarbazepine) (Controls unexposed, sick), 2013 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.98[0.76; 1.27]430532 -NAArtama (Oxcarbazepine) (Controls unexposed, sick), 2013 1 Tags Adjustment   - Yes  - Yes 0.98[0.76; 1.27]430532 -NAArtama (Oxcarbazepine) (Controls unexposed, sick), 2013 1 All studiesAll studies 0.98[0.76; 1.27]430532 -NAArtama (Oxcarbazepine) (Controls unexposed, sick), 2013 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 5927, 5910

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.21[0.97; 1.51]114,890532 -NAArtama (Oxcarbazepine) (Controls unexposed, disease free), 2013 1 unexposed, sick controlsunexposed, sick controls 0.98[0.76; 1.27]430532 -NAArtama (Oxcarbazepine) (Controls unexposed, sick), 2013 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.01[0.65; 1.57]131532 -NAArtama (Oxcarbazepine) (Controls exposed to Lamotrigine, sick), 2013 10.510.01.0