Oxcarbazepine (Epilepsy) updated on 04-22-2025

Severe cognitive developmental delay (Mental retardation) (> 6 years old)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15873
R65416		 Dreier (Oxcarbazepine) (Epilepsy) (Controls exposed to LTG), 2023 Intellectual disability - Corresponding ICD-10 F-chapter - Up to 22 years of age during pregnancy (anytime or not specified) population based cohort propective exposed to other treatment, sick excluded Adjustment: No 2.58 [1.53;4.37] C
excluded (control group) 		24/1,460   34/5,288 58 1,460
ref
S15874
R65431		 Dreier (Oxcarbazepine) (Epilepsy) (Controls unexposed, sick), 2023 Intellectual disability - Corresponding ICD-10 F-chapter - Up to 22 years of age during pregnancy (anytime or not specified) population based cohort propective unexposed, sick Adjustment: Yes 1.15 [0.71;1.89] 24/1,460   184/22,203 208 1,460
ref
Total 1 studies 1.15 [0.70;1.88] 208 1,460
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Dreier (Oxcarbazepine) (Epilepsy) (Controls unexposed, sick), 2023Dreier, 2023 1 1.15[0.71; 1.89]2081,4600%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Oxcarbazepine) (Epilepsy) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.15[0.70; 1.88]2081,460 -NADreier (Oxcarbazepine) (Epilepsy) (Controls unexposed, sick), 2023 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.15[0.70; 1.88]2081,460 -NADreier (Oxcarbazepine) (Epilepsy) (Controls unexposed, sick), 2023 1 Tags Adjustment   - Yes  - Yes 1.15[0.70; 1.88]2081,460 -NADreier (Oxcarbazepine) (Epilepsy) (Controls unexposed, sick), 2023 1 All studiesAll studies 1.15[0.70; 1.88]2081,460 -NADreier (Oxcarbazepine) (Epilepsy) (Controls unexposed, sick), 2023 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 15873

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.15[0.70; 1.88]2081,460 -NADreier (Oxcarbazepine) (Epilepsy) (Controls unexposed, sick), 2023 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 2.58[1.53; 4.37]581,460 -NADreier (Oxcarbazepine) (Epilepsy) (Controls exposed to LTG), 2023 10.510.01.0