Phenobarbital (Epilepsy)

Congenital heart defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6500
R17854		 Bànhidy (Phenobarbital), 2011 Cardiovascular congenital abnormalities throughout pregnancy case control unexposed, sick Adjustment: No Matched 2.11 [0.04;124.53] C 0/   5/15 5 0
ref
Total 1 studies 2.11 [0.04;124.53] 5 0
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bànhidy (Phenobarbital), 2011Bànhidy, 2011 1 2.11[0.04; 124.53]5-0%ROB confusion: criticalROB selection: criticalROB classification: lowROB missing: lowROB mesure: moderateROB reporting: moderate0.95.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Phenobarbital;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 2.11[0.04; 124.53]5- -NABànhidy (Phenobarbital), 2011 1 Type of controls unexposed, sickunexposed, sick 2.11[0.04; 124.53]5- -NABànhidy (Phenobarbital), 2011 1 Tags Adjustment   - No  - No 2.11[0.04; 124.53]5- -NABànhidy (Phenobarbital), 2011 1 MatchedMatched 2.11[0.04; 124.53]5- -NABànhidy (Phenobarbital), 2011 1 All studiesAll studies 2.11[0.04; 124.53]5- -NABànhidy (Phenobarbital), 2011 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale10.28[0.23; 452.32]21661%NAD'Souza (Phenobarbital) (Controls unexposed, disease free), 1991 Van der Pol (Phenobarbital) (Controls unexposed, disease free), 1991 2 unexposed, sick controlsunexposed, sick controls 1.77[0.69; 4.53]221530%NAThomas (Phenobarbital) (Controls unexposed, sick), 2021 Bànhidy (Phenobarbital), 2011 D'Souza (Phenobarbital) (Controls unexposed, sick), 1991 Van der Pol (Phenobarbital) (Controls unexposed, sick), 1991 4 exposed to other treatment, sick controlsexposed to other treatment, sick controls 5.62[2.55; 12.37]3863012%NAThomas (Phenobarbital) (Controls exposed to Lamotrigine, sick), 2021 Tomson (Phenobarbital), 2018 Hernández-Díaz (Phenobarbital) (Controls exposed to Lamotrigine, sick), 2012 30.510.01.0