Phenobarbital (Epilepsy)

Digestive system anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S12834
R48345		 Thomas (Phenobarbital) (Controls exposed to Lamotrigine, sick), 2021 Gastro-intestinal malformations 1st trimester prospective cohort exposed to other treatment, sick excluded Adjustment: No 0.36 [0.01;18.52] C
excluded (control group) 		0/137   0/50 0 137
ref
S12835
R48355		 Thomas (Phenobarbital) (Controls unexposed, sick), 2021 Gastro-intestinal malformations 1st trimester prospective cohort unexposed, sick Adjustment: No 0.83 [0.03;20.42] C 0/137   1/340 1 137
ref
Total 1 studies 0.83 [0.03;20.42] 1 137
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Thomas (Phenobarbital) (Controls unexposed, sick), 2021Thomas, 2021 1 0.83[0.03; 20.42]11370%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Phenobarbital) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.83[0.03; 20.42]1137 -NAThomas (Phenobarbital) (Controls unexposed, sick), 2021 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.83[0.03; 20.42]1137 -NAThomas (Phenobarbital) (Controls unexposed, sick), 2021 1 Tags Adjustment   - No  - No 0.83[0.03; 20.42]1137 -NAThomas (Phenobarbital) (Controls unexposed, sick), 2021 1 All studiesAll studies 0.83[0.03; 20.42]1137 -NAThomas (Phenobarbital) (Controls unexposed, sick), 2021 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 12834

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.83[0.03; 20.42]1137 -NAThomas (Phenobarbital) (Controls unexposed, sick), 2021 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.36[0.01; 18.52]-137 -NAThomas (Phenobarbital) (Controls exposed to Lamotrigine, sick), 2021 10.510.01.0