Primidone (Epilepsy)

Major congenital malformations

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6502
R17883		 Bànhidy (Primidone), 2011 Total congenital abnormalities throughout pregnancy case control unexposed, sick Adjustment: No Matched 0.56 [0.12;2.54] C 4/10   12/22 16 10
ref
Total 1 studies 0.56 [0.12;2.54] 16 10
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bànhidy (Primidone), 2011Bànhidy, 2011 1 0.56[0.12; 2.54]16100%ROB confusion: criticalROB selection: criticalROB classification: lowROB missing: lowROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Primidone;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0.56[0.12; 2.54]1610 -NABànhidy (Primidone), 2011 1 Type of controls unexposed, sickunexposed, sick 0.56[0.12; 2.54]1610 -NABànhidy (Primidone), 2011 1 Tags Adjustment   - No  - No 0.56[0.12; 2.54]1610 -NABànhidy (Primidone), 2011 1 MatchedMatched 0.56[0.12; 2.54]1610 -NABànhidy (Primidone), 2011 1 All studiesAll studies 0.56[0.12; 2.54]1610 -NABànhidy (Primidone), 2011 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.91[0.11; 32.49]2918 -NASamrén (Primidone), 1999 1 unexposed, sick controlsunexposed, sick controls 3.66[0.72; 18.70]285547%NAVajda (Primidone) (Controls unexposed, sick), 2019 Bànhidy (Primidone), 2011 Kaaja (Primidone), 2003 Dean (Primidone), 2002 Canger (Primidone), 1999 5 exposed to other treatment, sick controlsexposed to other treatment, sick controls 2.96[0.96; 9.12]97420%NAVajda (Primidone) (Controls exposed to Lamotrigine, sick), 2019 Tomson (Primidone), 2018 20.510.01.0