Primidone (Epilepsy) updated on 04-22-2025

Microcephaly / Small head circumference for gestational age

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6437
R17693		 Battino (Primidone), 1999 Small head circumferences (at birth < 10th percentile) throughout pregnancy prospective cohort unexposed, sick Adjustment: No 2.33 [0.55;9.99] C 7/34   3/30 10 34
ref
Total 1 studies 2.33 [0.55;9.99] 10 34
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Battino (Primidone), 1999Battino, 1999 1 2.33[0.55; 9.99]10340%ROB confusion: criticalROB selection: lowROB classification: lowROB missing: moderateROB mesure: moderateROB reporting: moderate0.95.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Primidone;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.33[0.55; 9.99]1034 -NABattino (Primidone), 1999 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.33[0.55; 9.99]1034 -NABattino (Primidone), 1999 1 Tags Adjustment   - No  - No 2.33[0.55; 9.99]1034 -NABattino (Primidone), 1999 1 All studiesAll studies 2.33[0.55; 9.99]1034 -NABattino (Primidone), 1999 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 2.33[0.55; 9.99]1034 -NABattino (Primidone), 1999 10.510.01.0