Primidone (Epilepsy) updated on 04-22-2025

Feeding difficulty

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6622
R18195		 Burja (Primidone) (Controls unexposed, disease free), 2006 Feeding problems during pregnancy (anytime or not specified) retrospective cohort (registry) unexposed, disease free excluded Adjustment: No 27.13 [0.50;1462.54] C
excluded (control group) 		0/1   7/211 7 1
ref
S6618
R18175		 Burja (Primidone) (Controls unexposed, sick), 2006 Feeding problems during pregnancy (anytime or not specified) retrospective cohort (registry) unexposed, sick Adjustment: No 20.33 [0.29;1423.95] C 0/1   1/32 1 1
ref
Total 1 studies 20.33 [0.29;1423.95] 1 1
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Burja (Primidone) (Controls unexposed, sick), 2006Burja, 2006 1 20.33[0.29; 1423.95]110%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.950.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Primidone) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 20.33[0.29; 1423.95]11 -NABurja (Primidone) (Controls unexposed, sick), 2006 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 20.33[0.29; 1423.95]11 -NABurja (Primidone) (Controls unexposed, sick), 2006 1 Tags Adjustment   - No  - No 20.33[0.29; 1423.95]11 -NABurja (Primidone) (Controls unexposed, sick), 2006 1 All studiesAll studies 20.33[0.29; 1423.95]11 -NABurja (Primidone) (Controls unexposed, sick), 2006 10.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 6622

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale27.13[0.50; 1462.54]71 -NABurja (Primidone) (Controls unexposed, disease free), 2006 1 unexposed, sick controlsunexposed, sick controls Out of scale20.33[0.29; 1423.95]11 -NABurja (Primidone) (Controls unexposed, sick), 2006 10.510.01.0