Pregabalin (Epilepsy) updated on 04-22-2025

Severe cognitive developmental delay (Mental retardation) (3-6 years old)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17254
R72214		 Madley-Dowd_UK (Pregabalin) (Controls unexposed, sick) (Epilepsy), 2024 Intellectual disability - ICD10 codes - Mean 5 years old during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, sick Adjustment: Yes 17.70 [0.97;322.22] C 0/9   13/4,075 13 9
ref
Total 1 studies 17.70 [0.97;322.22] 13 9
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Madley-Dowd_UK (Pregabalin) (Controls unexposed, sick) (Epilepsy), 2024Madley-Dowd_UK, 2024 1 17.70[0.97; 322.22]1390%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: unclearROB mesure: criticalROB reporting: moderate0.950.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Pregabalin) (Controls unexposed, sick) (Epilepsy;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 17.70[0.97; 322.22]139 -NAMadley-Dowd_UK (Pregabalin) (Controls unexposed, sick) (Epilepsy), 2024 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 17.70[0.97; 322.22]139 -NAMadley-Dowd_UK (Pregabalin) (Controls unexposed, sick) (Epilepsy), 2024 1 Tags Adjustment   - Yes  - Yes 17.70[0.97; 322.22]139 -NAMadley-Dowd_UK (Pregabalin) (Controls unexposed, sick) (Epilepsy), 2024 1 All studiesAll studies 17.70[0.97; 322.22]139 -NAMadley-Dowd_UK (Pregabalin) (Controls unexposed, sick) (Epilepsy), 2024 10.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale17.70[0.97; 322.22]139 -NAMadley-Dowd_UK (Pregabalin) (Controls unexposed, sick) (Epilepsy), 2024 10.510.01.0