Pregabalin (Epilepsy) updated on 04-22-2025

ADHD (Attention deficit hyperactivity disorder): Diagnosis/Risk

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17403
R73273		 Madley-Dowd_SE (Pregabalin) (Controls exposed to LTG), 2024 Attention Deficit Hyperactivity Disorder - ICD-8/9/10 codes and/or ADHD medication prescription - Mean 5-20 years old (according groups) during pregnancy (anytime or not specified) population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 0.23 [0.01;3.81] C
excluded (control group) 		0/45   109/2,383 109 45
ref
S17404
R72970		 Madley-Dowd_SE (Pregabalin) (Controls unexposed, sick), 2024 Attention Deficit Hyperactivity Disorder - ICD-8/9/10 codes and/or ADHD medication prescription - Mean 5-20 years old (according groups) during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: No 0.12 [0.01;1.93] C 0/45   929/10,769 929 45
ref
S17254
R72263		 Madley-Dowd_UK (Pregabalin) (Controls unexposed, sick) (Epilepsy), 2024 Attention Deficit Hyperactivity Disorder - ICD10 codes and/or ADHD medication prescription - Median follow up 4.92 (3.07-7.25) years old during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, sick Adjustment: Yes 35.67 [8.47;150.20] -/9   38/4,075 - 9
ref
Total 2 studies 2.35 [0.01;624.13] 929 54
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Madley-Dowd_SE (Pregabalin) (Controls unexposed, sick), 2024Madley-Dowd_SE, 2024 1 0.12[0.01; 1.93]9294548%ROB confusion: criticalROB selection: lowROB classification: lowROB missing: lowROB mesure: moderateROB reporting: moderate Madley-Dowd_UK (Pregabalin) (Controls unexposed, sick) (Epilepsy), 2024Madley-Dowd_UK, 2024 2 35.67[8.47; 150.20]-952%ROB confusion: moderateROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 92% 2.35[0.01; 624.13]929540.0100.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Pregabalin) (Controls unexposed, sick; 2: Pregabalin) (Controls unexposed, sick) (Epilepsy;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.35[0.01; 624.13]9295492%NAMadley-Dowd_SE (Pregabalin) (Controls unexposed, sick), 2024 Madley-Dowd_UK (Pregabalin) (Controls unexposed, sick) (Epilepsy), 2024 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.35[0.01; 624.13]9295492%NAMadley-Dowd_SE (Pregabalin) (Controls unexposed, sick), 2024 Madley-Dowd_UK (Pregabalin) (Controls unexposed, sick) (Epilepsy), 2024 2 Tags Adjustment   - No  - No 0.12[0.01; 1.93]92945 -NAMadley-Dowd_SE (Pregabalin) (Controls unexposed, sick), 2024 1   - Yes  - Yes 35.67[8.47; 150.21]-9 -NAMadley-Dowd_UK (Pregabalin) (Controls unexposed, sick) (Epilepsy), 2024 1 All studiesAll studies 2.35[0.01; 624.13]9295492%NAMadley-Dowd_SE (Pregabalin) (Controls unexposed, sick), 2024 Madley-Dowd_UK (Pregabalin) (Controls unexposed, sick) (Epilepsy), 2024 20.0100.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 17403

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 2.35[0.01; 624.13]9585492%NAMadley-Dowd_SE (Pregabalin) (Controls unexposed, sick), 2024 Madley-Dowd_UK (Pregabalin) (Controls unexposed, sick) (Epilepsy), 2024 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.23[0.01; 3.81]10945 -NAMadley-Dowd_SE (Pregabalin) (Controls exposed to LTG), 2024 10.510.01.0