Pregabalin (Epilepsy) - Medication and Pregnancy KB

Pregabalin (Epilepsy) updated on 04-22-2025

Cognitive developmental disorders/delay (> 6 years old)

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S17403 R73275	Madley-Dowd_SE (Pregabalin) (Controls exposed to LTG), 2024	Intellectual disability (intelligence quotient below 70) - ICD-8/9/10 codes - Mean 5-20 years old (according groups)	during pregnancy (anytime or not specified)	population based cohort retrospective	exposed to other treatment, sick excluded	Adjustment: No	0.76 [0.05;12.67] ^C excluded (control group)	0/45 34/2,383	34	45		ref
S17404 R72973	Madley-Dowd_SE (Pregabalin) (Controls unexposed, sick), 2024	Intellectual disability (intelligence quotient below 70) - ICD-8/9/10 codes - Mean 5-20 years old (according groups)	during pregnancy (anytime or not specified)	population based cohort retrospective	unexposed, sick	Adjustment: No	0.61 [0.04;9.96] ^C	0/45 194/10,769	194	45		ref
					Total	1 studies	0.61 [0.04;9.96]		194	45
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Pregabalin) (Controls unexposed, sick;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 17403