Felbamate (Epilepsy = All indications) updated on 04-22-2025

All congenital malformations (majors, minors, majors and minors, or unspecified)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S16581
R69644		 Battino (Felbamate) (Epilepsy), 2024 Major congenital malformations (MCMs) early pregnancy prospective cohort exposed to other treatment, sick Adjustment: No 6.29 [0.30;131.73] C 0/3   110/3,584 110 3
ref
Total 1 studies 6.29 [0.30;131.73] 110 3
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Battino (Felbamate) (Epilepsy), 2024Battino, 2024 1 6.29[0.30; 131.73]11030%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: moderateROB mesure: moderateROB reporting: moderate0.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Felbamate) (Epilepsy;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 6.29[0.30; 131.73]1103 -NABattino (Felbamate) (Epilepsy), 2024 1 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 6.29[0.30; 131.73]1103 -NABattino (Felbamate) (Epilepsy), 2024 1 Tags Adjustment   - No  - No 6.29[0.30; 131.73]1103 -NABattino (Felbamate) (Epilepsy), 2024 1 All studiesAll studies 6.29[0.30; 131.73]1103 -NABattino (Felbamate) (Epilepsy), 2024 10.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls 6.29[0.30; 131.73]1103 -NABattino (Felbamate) (Epilepsy), 2024 10.510.01.0