Clomethiazol (Epilepsy = All indications)

Spina bifida

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6493
R17793		 Czeizel (Clomethiazol), 1992 Spina bifida throughout pregnancy case control unexposed, sick Adjustment: No 5.00 [0.04;711.87] C 0/   1/4 1 0
ref
Total 1 studies 5.00 [0.04;711.87] 1 0
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Czeizel (Clomethiazol), 1992Czeizel, 1992 1 5.00[0.04; 711.87]1-0%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Clomethiazol;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 5.00[0.04; 711.87]1- -NACzeizel (Clomethiazol), 1992 1 Type of controls unexposed, sickunexposed, sick 5.00[0.04; 711.87]1- -NACzeizel (Clomethiazol), 1992 1 Tags Adjustment   - No  - No 5.00[0.04; 711.87]1- -NACzeizel (Clomethiazol), 1992 1 All studiesAll studies 5.00[0.04; 711.87]1- -NACzeizel (Clomethiazol), 1992 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 5.00[0.04; 711.87]1- -NACzeizel (Clomethiazol), 1992 10.510.01.0