Clomethiazol (Epilepsy = All indications)

All congenital malformations (majors, minors, majors and minors, or unspecified)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6492
R35114		 Bànhidy (Clomethiazol), 2011 Total congenital abnormalities throughout pregnancy case control unexposed, sick Adjustment: No Matched 4.13 [0.18;96.94] C 2/2   12/22 14 2
ref
Total 1 studies 4.13 [0.18;96.94] 14 2
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bànhidy (Clomethiazol), 2011Bànhidy, 2011 1 4.13[0.18; 96.94]1420%ROB confusion: criticalROB selection: criticalROB classification: lowROB missing: lowROB mesure: moderateROB reporting: moderate0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Clomethiazol;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 4.13[0.18; 96.94]142 -NABànhidy (Clomethiazol), 2011 1 Type of controls unexposed, sickunexposed, sick 4.13[0.18; 96.94]142 -NABànhidy (Clomethiazol), 2011 1 Tags Adjustment   - No  - No 4.13[0.18; 96.94]142 -NABànhidy (Clomethiazol), 2011 1 MatchedMatched 4.13[0.18; 96.94]142 -NABànhidy (Clomethiazol), 2011 1 All studiesAll studies 4.13[0.18; 96.94]142 -NABànhidy (Clomethiazol), 2011 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 4.13[0.18; 96.94]142 -NABànhidy (Clomethiazol), 2011 10.510.01.0