Sultiame (Epilepsy = ALL)

All congenital malformations (majors, minors, majors and minors, or unspecified)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6503
R35129		 Bànhidy (Sultiame), 2011 Total congenital abnormalities throughout pregnancy case control unexposed, sick Adjustment: No Matched 0.83 [0.01;45.70] C 0/   12/22 12 0
ref
Total 1 studies 0.83 [0.01;45.70] 12 0
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bànhidy (Sultiame), 2011Bànhidy, 2011 1 0.83[0.01; 45.70]12-0%ROB confusion: criticalROB selection: criticalROB classification: lowROB missing: lowROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Sultiame;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0.83[0.01; 45.70]12- -NABànhidy (Sultiame), 2011 1 Type of controls unexposed, sickunexposed, sick 0.83[0.01; 45.70]12- -NABànhidy (Sultiame), 2011 1 Tags Adjustment   - No  - No 0.83[0.01; 45.70]12- -NABànhidy (Sultiame), 2011 1 MatchedMatched 0.83[0.01; 45.70]12- -NABànhidy (Sultiame), 2011 1 All studiesAll studies 0.83[0.01; 45.70]12- -NABànhidy (Sultiame), 2011 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale66.80[1.30; 3423.69]291 -NASamrén (Sultiame), 1999 1 unexposed, sick controlsunexposed, sick controls 0.83[0.01; 45.70]12- -NABànhidy (Sultiame), 2011 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale32.74[0.65; 1661.58]741 -NATomson (Sulthiame), 2018 10.510.01.0