Sultiame (Epilepsy = ALL)

Major congenital malformations

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7667
R22697		 Tomson (Sulthiame), 2018 Malformed Offspring at least 1st trimester prospective cohort exposed to other treatment, sick Adjustment: No 32.74 [0.65;1661.58] C 0/1   74/2,514 74 1
ref
S6503
R17894		 Bànhidy (Sultiame), 2011 Total congenital abnormalities throughout pregnancy case control unexposed, sick Adjustment: No Matched 0.83 [0.01;45.70] C 0/   12/22 12 0
ref
S6719
R18992		 Samrén (Sultiame), 1999 Major congential abnormalities at least 1st trimester retrospective cohort unexposed, disease free Adjustment: No Matched 66.80 [1.30;3423.69] C 0/1   29/2,000 29 1
ref
Total 3 studies 12.51 [0.88;176.98] 115 2
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Tomson (Sulthiame), 2018Tomson, 2018 1 32.74[0.65; 1661.58]74134%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Bànhidy (Sultiame), 2011Bànhidy, 2011 2 0.83[0.01; 45.70]12-33%ROB confusion: criticalROB selection: criticalROB classification: lowROB missing: lowROB mesure: moderateROB reporting: moderate Samrén (Sultiame), 1999Samrén, 1999 3 66.80[1.30; 3423.69]29134%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (3 studies) I2 = 26% 12.51[0.88; 176.98]11520.2500.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Sulthiame; 2: Sultiame; 3: Sultiame;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 46.73[2.90; 753.31]10320%NATomson (Sulthiame), 2018 Samrén (Sultiame), 1999 2 case control studiescase control studies 0.83[0.01; 45.70]12- -NABànhidy (Sultiame), 2011 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 66.80[1.30; 3423.69]291 -NASamrén (Sultiame), 1999 1 unexposed, sickunexposed, sick 0.83[0.01; 45.70]12- -NABànhidy (Sultiame), 2011 1 exposed to other treatment, sickexposed to other treatment, sick 32.74[0.65; 1661.58]741 -NATomson (Sulthiame), 2018 1 Tags Adjustment   - No  - No 12.51[0.88; 176.98]115226%NATomson (Sulthiame), 2018 Bànhidy (Sultiame), 2011 Samrén (Sultiame), 1999 3 MatchedMatched 7.56[0.10; 560.02]41157%NABànhidy (Sultiame), 2011 Samrén (Sultiame), 1999 2 All studiesAll studies 12.51[0.88; 176.98]115226%NATomson (Sulthiame), 2018 Bànhidy (Sultiame), 2011 Samrén (Sultiame), 1999 30.21000.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale66.80[1.30; 3423.69]291 -NASamrén (Sultiame), 1999 1 unexposed, sick controlsunexposed, sick controls 0.83[0.01; 45.70]12- -NABànhidy (Sultiame), 2011 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale32.74[0.65; 1661.58]741 -NATomson (Sulthiame), 2018 10.510.01.0