Piracetam (Epilepsy = All indications)

Major congenital malformations

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6073
R15806		 Morrow (Piracetam) (Controls exposed to Lamotrigine, sick), 2006 Major congenital malformation 1st trimester prospective cohort exposed to other treatment, sick excluded Adjustment: No 29.09 [0.56;1501.17] C
excluded (control group) 		0/1   21/647 21 1
ref
S6074
R15813		 Morrow (Piracetam) (Controls unexposed, sick), 2006 Major congenital malformation 1st trimester prospective cohort unexposed, sick Adjustment: No 25.71 [0.48;1374.93] C 0/1   8/227 8 1
ref
Total 1 studies 25.71 [0.48;1374.93] 8 1
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Morrow (Piracetam) (Controls unexposed, sick), 2006Morrow, 2006 1 25.71[0.48; 1374.93]810%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.9100.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Piracetam) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 25.71[0.48; 1374.93]81 -NAMorrow (Piracetam) (Controls unexposed, sick), 2006 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 25.71[0.48; 1374.93]81 -NAMorrow (Piracetam) (Controls unexposed, sick), 2006 1 Tags Adjustment   - No  - No 25.71[0.48; 1374.93]81 -NAMorrow (Piracetam) (Controls unexposed, sick), 2006 1 All studiesAll studies 25.71[0.48; 1374.93]81 -NAMorrow (Piracetam) (Controls unexposed, sick), 2006 10.5100.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 6073

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale25.71[0.48; 1374.93]81 -NAMorrow (Piracetam) (Controls unexposed, sick), 2006 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale29.09[0.56; 1501.17]211 -NAMorrow (Piracetam) (Controls exposed to Lamotrigine, sick), 2006 10.510.01.0