Methsuximide (Epilepsy = All indications) - Medication and Pregnancy KB

Methsuximide (Epilepsy = All indications) updated on 04-22-2025

All congenital malformations (majors, minors, majors and minors, or unspecified)

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S16584 R69650	Battino (Methsuximide) (Epilepsy), 2024	Major congenital malformations (MCMs)	early pregnancy	prospective cohort	exposed to other treatment, sick	Adjustment: No	31.43 [0.62;1591.57] ^C	0/1 110/3,584	110	1		ref
S6714 R26937	Samrén (Methsuximide), 1999	Major congential abnormalities	at least 1st trimester	retrospective cohort	unexposed, disease free	Adjustment: No Matched	66.80 [1.30;3423.69] ^C	0/1 29/2,000	29	1		ref
					Total	2 studies	45.77 [2.84;737.32]		139	2
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Methsuximide) (Epilepsy; 2: Methsuximide;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded