Gabapentin (All indications)

Bladder exstrophy and/or epispadia

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S10033
R36118		 Blotière (Controls exposed to Lamotrigine, sick) (Other indications), 2019 Epispadias 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No Controls: mixed indications 2.74 [0.11;67.37] C
excluded (control group) 		0/365   1/2,997 1 365
ref
S10034
R36141		 Blotière (Controls unexposed NOS) (Other indications), 2019 Epispadias 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No 31.19 [1.93;503.78] C 0/365   82/1,875,733 82 365
ref
Total 1 studies 31.19 [1.93;503.78] 82 365
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Blotière (Controls unexposed NOS) (Other indications), 2019Blotière, 2019 1 31.19[1.93; 503.78]823650%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.9100.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed NOS) (Other indications;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 31.19[1.93; 503.78]82365 -NABlotière (Controls unexposed NOS) (Other indications), 2019 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 31.19[1.93; 503.78]82365 -NABlotière (Controls unexposed NOS) (Other indications), 2019 1 Tags Adjustment   - No  - No 31.19[1.93; 503.78]82365 -NABlotière (Controls unexposed NOS) (Other indications), 2019 1 All studiesAll studies 31.19[1.93; 503.78]82365 -NABlotière (Controls unexposed NOS) (Other indications), 2019 10.5100.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 10033

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale31.19[1.93; 503.78]82365 -NABlotière (Controls unexposed NOS) (Other indications), 2019 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 2.74[0.11; 67.37]1365 -NABlotière (Controls exposed to Lamotrigine, sick) (Other indications), 2019 10.510.01.0