Gabapentin (All indications) updated on 04-22-2025

Cognitive developmental disorders/delay (> 6 years old)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S8543
R53784		 Bromley, 2016 Full-scale IQ <85 (Wechsler Preschool and Primary Scale of Intelligence (WPPSI) / Wechsler Intelligence Scale for Children (WISC)) (5-9 years old) during pregnancy (anytime or not specified) retrospective cohort (registry) unexposed, sick Adjustment: No 1.33 [0.13;13.89] C 1/14   3/55 4 14
ref
Total 1 studies 1.33 [0.13;13.89] 4 14
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bromley, 2016Bromley, 2016 1.33[0.13; 13.89]4140%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.33[0.13; 13.89]414 -NABromley, 2016 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.33[0.13; 13.89]414 -NABromley, 2016 1 Tags Adjustment   - No  - No 1.33[0.13; 13.89]414 -NABromley, 2016 1 All studiesAll studies 1.33[0.13; 13.89]414 -NABromley, 2016 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.33[0.13; 13.89]414 -NABromley, 2016 10.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Veroniki b (NMA) (Cognitive Developmental Delay)Veroniki b (NMA) (Cognitive Developmental Delay) 1.46[0.04; 13.48]NA-Wwhatever (meta-analysis)Anyduring pregnancy (anytime or not specified)studies TTT-9 metaPregmetaPreg 1.33[0.13; 13.89]NaN%14----Bromley, 2016 10.510.01.0