id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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S15270 R62757 |
Desrochers, 2022 | Cardiac malformations | 1st trimester | retrospective cohort (claims database) | unexposed (general population or NOS) | Adjustment: Yes | 1.29 [0.72;2.31] | -/- -/288,357 | - | - |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S8491 R35398 |
Miškov (Controls unexposed, disease free), 2016 | Congenital heart defect | during pregnancy (anytime or not specified) | prospective cohort | unexposed, disease free excluded | Adjustment: No |
765.00 [11.05;52971.87] C excluded (control group) |
1/2 0/128 | 1 | 2 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S8492 R35405 |
Miškov (Controls unexposed, sick), 2016 | Congenital heart defect | during pregnancy (anytime or not specified) excluded | prospective cohort | unexposed, sick | Adjustment: No |
21.00 [0.27;1646.32] C excluded (exposition period) |
1/2 0/4 | 1 | 2 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S8493 R27900 |
Morrow (Controls exposed to Lamotrigine, sick), 2006 | Cardiac | 1st trimester | prospective cohort | exposed to other treatment, sick | Adjustment: No | 5.36 [0.58;49.42] C | 1/31 4/647 | 5 | 31 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Total | 2 studies | 1.73 [0.56;5.33] | 5 | 31 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives |
1: Controls exposed to Lamotrigine, sick;
Funnel plot not drawn. Less than 3 points.
Asymetry test p-value = NaN (by Egger's regression)
not enought points
Funnel plot not drawn. Less than 3 points.
excluded 8491