Gabapentin (All indications) updated on 04-22-2025

Elective/induced termination of pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S19340
R81984		 Moore (Controls exposed to LTG) (Indication NOS), 2025 Elective termination of pregnancy during pregnancy (anytime or not specified) population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 1.42 [1.22;1.65] C
excluded (control group) 		591/2,363   351/1,846 942 2,363
ref
S19334
R81960		 Moore (Controls unexposed, general pop) (Indication NOS), 2025 Elective termination of pregnancy during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Matched 1.32 [1.17;1.49] 591/2,363   3,857/21,668 4,448 2,363
ref
S8490
R27881		 Miškov (Controls exposed to Lamotrigine, sick), 2016 Artificial abortion during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick excluded Adjustment: No 7.89 [0.22;286.86] C
excluded (control group) 		0/2   1/37 1 2
ref
S8491
R27886		 Miškov (Controls unexposed, disease free), 2016 Artificial abortion during pregnancy (anytime or not specified) prospective cohort unexposed, disease free excluded Adjustment: No 85.00 [1.23;5885.76] C
excluded (control group) 		0/2   0/128 0 2
ref
S8492
R27892		 Miškov (Controls unexposed, sick), 2016 Artificial abortion during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No 2.33 [0.03;182.92] C 0/2   0/4 0 2
ref
Total 2 studies 1.32 [1.17;1.49] 4,448 2,365
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Moore (Controls unexposed, general pop) (Indication NOS), 2025Moore, 2025 1 1.32[1.17; 1.49]4,4482,363100%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: low Miškov (Controls unexposed, sick), 2016Miškov, 2016 2 2.33[0.03; 182.92]020%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: criticalROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.32[1.17; 1.49]4,4482,3650.55.01.0ROB: A: confounding, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, general pop) (Indication NOS; 2: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.32[1.17; 1.49]4,4482,3650%NAMoore (Controls unexposed, general pop) (Indication NOS), 2025 Miškov (Controls unexposed, sick), 2016 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.32[1.17; 1.49]4,4482,363 -NAMoore (Controls unexposed, general pop) (Indication NOS), 2025 1 unexposed, sickunexposed, sick 2.33[0.03; 182.92]-2 -NAMiškov (Controls unexposed, sick), 2016 1 Tags Adjustment   - No  - No 2.33[0.03; 182.92]-2 -NAMiškov (Controls unexposed, sick), 2016 1   - Yes  - Yes 1.32[1.17; 1.49]4,4482,363 -NAMoore (Controls unexposed, general pop) (Indication NOS), 2025 1 MatchedMatched 1.32[1.17; 1.49]4,4482,363 -NAMoore (Controls unexposed, general pop) (Indication NOS), 2025 1 All studiesAll studies 1.32[1.17; 1.49]4,4482,3650%NAMoore (Controls unexposed, general pop) (Indication NOS), 2025 Miškov (Controls unexposed, sick), 2016 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 8490, 8491, 19340

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 6.05[0.12; 308.10]4,4482,36573%NAMoore (Controls unexposed, general pop) (Indication NOS), 2025 Miškov (Controls unexposed, disease free), 2016 2 unexposed, sick controlsunexposed, sick controls 2.33[0.03; 182.92]-2 -NAMiškov (Controls unexposed, sick), 2016 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.42[1.23; 1.65]9432,3650%NAMoore (Controls exposed to LTG) (Indication NOS), 2025 Miškov (Controls exposed to Lamotrigine, sick), 2016 20.510.01.0