Pregabalin (All indications) - Medication and Pregnancy KB

Pregabalin (All indications) updated on 04-22-2025

ASD (Autism spectrum disorder): Diagnosis

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S17417 R73107	Madley-Dowd_SE (Pregabalin) (Controls exposed to LTG) (Mixed indications), 2024	Autism - ICD-8/9/10 codes - Mean 5-20 years old (according groups)	during pregnancy (anytime or not specified)	population based cohort retrospective	exposed to other treatment, sick excluded	Adjustment: Yes Partial overlapping	0.85 [0.60;1.18] excluded (control group)	47/1,307 134/5,035	181	1,307		ref
S17418 R73113	Madley-Dowd_SE (Pregabalin) (Controls unexposed, general pop) (Mixed indications), 2024	Autism - ICD-8/9/10 codes - Mean 5-20 years old (according groups)	during pregnancy (anytime or not specified)	population based cohort retrospective	unexposed (general population or NOS)	Adjustment: Yes Partial overlapping	0.70 [0.53;0.93]	47/1,307 68,788/2,651,210	68,835	1,307		ref
S17419 R73119	Madley-Dowd_SE (Pregabalin) (Controls unexposed, sibling) (Mixed indications), 2024	Autism - ICD-8/9/10 codes - Mean 5-20 years old (according groups)	during pregnancy (anytime or not specified)	population based cohort retrospective	sibling excluded	Adjustment: Yes Partial overlapping	1.24 [0.63;2.42] excluded (control group)	-/- -/-	-	-		ref
S17284 R72335	Madley-Dowd_UK (Pregabalin) (Controls exposed to LTG) (Mixed indications), 2024	Autism - ICD10 codes - Median follow up 4.92 (3.07-7.25) years old	during pregnancy (anytime or not specified)	retrospective cohort (claims database)	exposed to other treatment, sick excluded	Adjustment: Yes	0.72 [0.30;1.76] excluded (control group)	7/408 20/939	27	408		ref
S17269 R72291	Madley-Dowd_UK (Pregabalin) (Controls unexposed, general pop) (Mixed indications), 2024	Autism - ICD10 codes - Median follow up 4.92 (3.07-7.25) years old	during pregnancy (anytime or not specified)	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: Yes	0.79 [0.37;1.67]	7/408 7,657/514,066	7,664	408		ref
S17277 R72315	Madley-Dowd_UK (Pregabalin) (Controls unexposed, sibling) (Mixed indications), 2024	Autism - ICD10 codes - Median follow up 4.92 (3.07-7.25) years old	during pregnancy (anytime or not specified)	retrospective cohort (claims database)	sibling excluded	Adjustment: Yes	0.54 [0.23;1.28] excluded (control group)	-/- -/-	-	-		ref
S12754 R48119	Bjørk (Controls exposed to Lamotrigine, sick) (Mixed indications), 2022	Diagnosis of childhood autism (F84.0), atypical autism (F84.1), and Asperger syndrome (F84.5) - Median follow up pregabalin, 5.2 (2.7-7.5) years old	during pregnancy (anytime or not specified)	population based cohort retrospective	exposed to other treatment, sick excluded	Adjustment: No Controls: mixed indications	0.93 [0.54;1.59] ^C excluded (control group)	16/1,666 82/7,950	98	1,666		ref
S12755 R48122	Bjørk (Controls unexposed NOS) (Mixed indications), 2022	Diagnosis of childhood autism (F84.0), atypical autism (F84.1), and Asperger syndrome (F84.5) - Median follow up pregabalin, 5.2 (2.7-7.5) years old	during pregnancy (anytime or not specified)	population based cohort retrospective	unexposed (general population or NOS) excluded	Adjustment: Yes	1.01 [0.62;1.66] excluded (control group)	16/1,666 38,437/4,463,879	38,453	1,666		ref
S12756 R48125	Bjørk (Controls unexposed, sick) (Mixed indications), 2022	Diagnosis of childhood autism (F84.0), atypical autism (F84.1), and Asperger syndrome (F84.5) - Median follow up pregabalin, 5.2 (2.7-7.5) years old	during pregnancy (anytime or not specified)	population based cohort retrospective	unexposed, sick	Adjustment: No Controls: epilepsy indication	0.78 [0.47;1.29] ^C	16/1,666 267/21,634	283	1,666		ref
S10100 R36798	Coste (Controls exposed to Lamotrigine, sick) (Mixed indications), 2020	Diagnosis Pervasive developmental disorders (F84) (mean age of 3.7 years old)	during pregnancy (anytime or not specified)	retrospective cohort (claims database)	exposed to other treatment, sick excluded	Adjustment: Yes	1.10 [0.40;3.00] excluded (control group)	7/1,627 11/2,916	18	1,627		ref
S8541 R28344	Coste (Controls unexposed, NOS) (Mixed indications), 2020	Diagnosis Pervasive developmental disorders (F84) (mean age of 3.6 years old)	during pregnancy (anytime or not specified)	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: Yes	1.40 [0.70;2.90]	7/1,627 4,280/1,710,441	4,287	1,627		ref
					Total	4 studies	0.78 [0.62;0.99]		81,069	5,008
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Pregabalin) (Controls unexposed, general pop) (Mixed indications; 2: Pregabalin) (Controls unexposed, general pop) (Mixed indications; 3: Controls unexposed, sick) (Mixed indications; 4: Controls unexposed, NOS) (Mixed indications;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Sub-groups analysis using all included studies

excluded 10100, 12754, 12755, 17417, 17419, 17284, 17277