Pregabalin (All indications) updated on 04-22-2025

Hydrocephaly

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S19317
R81837		 Kim (Controls unexposed, NOS) (Pregabalin) (Indications NOS), 2026 Congenital hydrocephalus 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes 4.53 [0.63;32.48] 1/449   1,066/2,489,078 1,067 449
ref
Total 1 studies 4.53 [0.63;32.53] 1,067 449
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Kim (Controls unexposed, NOS) (Pregabalin) (Indications NOS), 2026Kim, 2026 1 4.53[0.63; 32.48]1,0674490%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate0.910.01.0ROB: A: confounding, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, NOS) (Pregabalin) (Indications NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 4.53[0.63; 32.53]1,067449 -NAKim (Controls unexposed, NOS) (Pregabalin) (Indications NOS), 2026 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 4.53[0.63; 32.53]1,067449 -NAKim (Controls unexposed, NOS) (Pregabalin) (Indications NOS), 2026 1 Tags Adjustment   - Yes  - Yes 4.53[0.63; 32.53]1,067449 -NAKim (Controls unexposed, NOS) (Pregabalin) (Indications NOS), 2026 1 All studiesAll studies 4.53[0.63; 32.53]1,067449 -NAKim (Controls unexposed, NOS) (Pregabalin) (Indications NOS), 2026 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 4.53[0.63; 32.53]1,067449 -NAKim (Controls unexposed, NOS) (Pregabalin) (Indications NOS), 2026 10.510.01.0