Pregabalin (All indications) updated on 04-22-2025

Severe congenital heart defect

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S19303
R81717		 Beau (Indications NOS), 2026 Severe congenital heart defects 1st trimester case control unexposed (general population or NOS) Adjustment: Yes 2.87 [0.85;9.73] 3/13   11,842/105,815 11,845 13
ref
Total 1 studies 2.87 [0.85;9.71] 11,845 13
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Beau (Indications NOS), 2026Beau, 2026 1 2.87[0.85; 9.73]11,845130%ROB confusion: criticalROB selection: criticalROB classification: unclearROB missing: lowROB mesure: moderateROB reporting: moderate0.910.01.0ROB: A: confounding, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Indications NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 2.87[0.85; 9.71]11,84513 -NABeau (Indications NOS), 2026 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.87[0.85; 9.71]11,84513 -NABeau (Indications NOS), 2026 1 Tags Adjustment   - Yes  - Yes 2.87[0.85; 9.71]11,84513 -NABeau (Indications NOS), 2026 1 All studiesAll studies 2.87[0.85; 9.71]11,84513 -NABeau (Indications NOS), 2026 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.87[0.85; 9.71]11,84513 -NABeau (Indications NOS), 2026 10.510.01.0