Pregabalin (All indications) updated on 04-22-2025

Severe cognitive developmental delay (Mental retardation) (> 6 years old)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17417
R73108		 Madley-Dowd_SE (Pregabalin) (Controls exposed to LTG) (Mixed indications), 2024 Intellectual disability (intelligence quotient below 70) - ICD-8/9/10 codes - Mean 5-20 years old (according groups) during pregnancy (anytime or not specified) population based cohort retrospective exposed to other treatment, sick excluded Adjustment: Yes 0.78 [0.45;1.37]
excluded (control group) 		16/1,307   60/5,035 76 1,307
ref
S17418
R73114		 Madley-Dowd_SE (Pregabalin) (Controls unexposed, general pop) (Mixed indications), 2024 Intellectual disability (intelligence quotient below 70) - ICD-8/9/10 codes - Mean 5-20 years old (according groups) during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes 0.86 [0.52;1.40] 16/1,307   24,323/2,651,210 24,339 1,307
ref
S17419
R73120		 Madley-Dowd_SE (Pregabalin) (Controls unexposed, sibling) (Mixed indications), 2024 Intellectual disability (intelligence quotient below 70) - ICD-8/9/10 codes - Mean 5-20 years old (according groups) during pregnancy (anytime or not specified) population based cohort retrospective sibling excluded Adjustment: Yes 0.77 [0.26;2.26]
excluded (control group) 		-/-   -/- - -
ref
Total 1 studies 0.86 [0.52;1.41] 24,339 1,307
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Madley-Dowd_SE (Pregabalin) (Controls unexposed, general pop) (Mixed indications), 2024Madley-Dowd_SE, 2024 1 0.86[0.52; 1.40]24,3391,3070%ROB confusion: seriousROB selection: lowROB classification: lowROB missing: lowROB mesure: criticalROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Pregabalin) (Controls unexposed, general pop) (Mixed indications;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.86[0.52; 1.41]24,3391,307 -NAMadley-Dowd_SE (Pregabalin) (Controls unexposed, general pop) (Mixed indications), 2024 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.86[0.52; 1.41]24,3391,307 -NAMadley-Dowd_SE (Pregabalin) (Controls unexposed, general pop) (Mixed indications), 2024 1 Tags Adjustment   - Yes  - Yes 0.86[0.52; 1.41]24,3391,307 -NAMadley-Dowd_SE (Pregabalin) (Controls unexposed, general pop) (Mixed indications), 2024 1 All studiesAll studies 0.86[0.52; 1.41]24,3391,307 -NAMadley-Dowd_SE (Pregabalin) (Controls unexposed, general pop) (Mixed indications), 2024 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 17417, 17419

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.86[0.52; 1.41]24,3391,307 -NAMadley-Dowd_SE (Pregabalin) (Controls unexposed, general pop) (Mixed indications), 2024 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.78[0.45; 1.36]761,307 -NAMadley-Dowd_SE (Pregabalin) (Controls exposed to LTG) (Mixed indications), 2024 1 siblingssiblings 0.77[0.26; 2.27]-- -NAMadley-Dowd_SE (Pregabalin) (Controls unexposed, sibling) (Mixed indications), 2024 10.510.01.0