Pregabalin (All indications)

Extremely preterm (< 28 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S8541
R28334		 Coste (Controls unexposed, NOS) (Mixed indications), 2020 Gestational age at birth (22-26 WA) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No 1.55 [0.50;4.80] C 3/1,627   2,041/1,710,441 2,044 1,627
ref
Total 1 studies 1.55 [0.50;4.80] 2,044 1,627
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Coste (Controls unexposed, NOS) (Mixed indications), 2020Coste, 2020 1 1.55[0.50; 4.80]2,0441,6270%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, NOS) (Mixed indications;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.55[0.50; 4.80]2,0441,627 -NACoste (Controls unexposed, NOS) (Mixed indications), 2020 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.55[0.50; 4.80]2,0441,627 -NACoste (Controls unexposed, NOS) (Mixed indications), 2020 1 Tags Adjustment   - No  - No 1.55[0.50; 4.80]2,0441,627 -NACoste (Controls unexposed, NOS) (Mixed indications), 2020 1 All studiesAll studies 1.55[0.50; 4.80]2,0441,627 -NACoste (Controls unexposed, NOS) (Mixed indications), 2020 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.55[0.50; 4.80]2,0441,627 -NACoste (Controls unexposed, NOS) (Mixed indications), 2020 10.510.01.0