Topiramate (All indications) updated on 04-22-2025

Preeclampsia

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S8592
R28594		 Cohen (Topiramate) (Controls exposed to Lamotrigine, sick) (Mixed indications), 2019 Preeclampsia early pregnancy retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: Yes 0.61 [0.41;0.90]
excluded (control group) 		131/2,280   129/2,682 260 2,280
ref
S8593
R28601		 Cohen (Topiramate) (Controls unexposed NOS) (Mixed indications), 2019 Preeclampsia early pregnancy retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 1.06 [0.89;1.26] 131/2,280   53,634/1,440,631 53,765 2,280
ref
Total 1 studies 1.06 [0.89;1.26] 53,765 2,280
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Cohen (Topiramate) (Controls unexposed NOS) (Mixed indications), 2019Cohen, 2019 1 1.06[0.89; 1.26]53,7652,2800%ROB confusion: moderateROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Topiramate) (Controls unexposed NOS) (Mixed indications;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.06[0.89; 1.26]53,7652,280 -NACohen (Topiramate) (Controls unexposed NOS) (Mixed indications), 2019 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.06[0.89; 1.26]53,7652,280 -NACohen (Topiramate) (Controls unexposed NOS) (Mixed indications), 2019 1 Tags Adjustment   - Yes  - Yes 1.06[0.89; 1.26]53,7652,280 -NACohen (Topiramate) (Controls unexposed NOS) (Mixed indications), 2019 1 All studiesAll studies 1.06[0.89; 1.26]53,7652,280 -NACohen (Topiramate) (Controls unexposed NOS) (Mixed indications), 2019 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 8592

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.06[0.89; 1.26]53,7652,280 -NACohen (Topiramate) (Controls unexposed NOS) (Mixed indications), 2019 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.61[0.41; 0.90]2602,280 -NACohen (Topiramate) (Controls exposed to Lamotrigine, sick) (Mixed indications), 2019 10.510.01.0