Topiramate (All indications) updated on 04-22-2025

Ventricular septal defect

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S10173
R37181		 Blotière (Topiramate) (Controls exposed to Lamotrigine, sick) (Mixed indications), 2019 Ventricular septal defect 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 1.16 [0.25;5.31] C
excluded (control group) 		2/517   10/2,997 12 517
ref
S10048
R36432		 Blotière (Topiramate) (Controls unexposed NOS) (Mixed indications), 2019 Ventricular septal defect 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No 1.60 [0.20;5.80] 2/517   4,643/1,875,733 4,645 517
ref
Total 1 studies 1.60 [0.30;8.62] 4,645 517
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Blotière (Topiramate) (Controls unexposed NOS) (Mixed indications), 2019Blotière, 2019 1 1.60[0.20; 5.80]4,6455170%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Topiramate) (Controls unexposed NOS) (Mixed indications;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.60[0.30; 8.62]4,645517 -NABlotière (Topiramate) (Controls unexposed NOS) (Mixed indications), 2019 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.60[0.30; 8.62]4,645517 -NABlotière (Topiramate) (Controls unexposed NOS) (Mixed indications), 2019 1 Tags Adjustment   - No  - No 1.60[0.30; 8.62]4,645517 -NABlotière (Topiramate) (Controls unexposed NOS) (Mixed indications), 2019 1 All studiesAll studies 1.60[0.30; 8.62]4,645517 -NABlotière (Topiramate) (Controls unexposed NOS) (Mixed indications), 2019 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 10173

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.60[0.30; 8.62]4,645517 -NABlotière (Topiramate) (Controls unexposed NOS) (Mixed indications), 2019 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.16[0.25; 5.31]12517 -NABlotière (Topiramate) (Controls exposed to Lamotrigine, sick) (Mixed indications), 2019 10.510.01.0