Topiramate (All indications) updated on 04-22-2025

Low Apgar score (< 7) (at 1 min)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S8602
R28636		 Bank (Topiramate) (Mixed indications) , 2017 Apgar < 7 at 1 minute during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick Adjustment: No 4.47 [0.14;140.56] C 0/2   2/36 2 2
ref
Total 1 studies 4.47 [0.14;140.56] 2 2
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bank (Topiramate) (Mixed indications) , 2017Bank, 2017 1 4.47[0.14; 140.56]220%ROB confusion: criticalROB selection: lowROB classification: lowROB missing: lowROB mesure: moderateROB reporting: moderate0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Topiramate) (Mixed indications;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 4.47[0.14; 140.56]22 -NABank (Topiramate) (Mixed indications) , 2017 1 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 4.47[0.14; 140.56]22 -NABank (Topiramate) (Mixed indications) , 2017 1 Tags Adjustment   - No  - No 4.47[0.14; 140.56]22 -NABank (Topiramate) (Mixed indications) , 2017 1 All studiesAll studies 4.47[0.14; 140.56]22 -NABank (Topiramate) (Mixed indications) , 2017 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls 4.47[0.14; 140.56]22 -NABank (Topiramate) (Mixed indications) , 2017 10.510.01.0