Topiramate (All indications) - Medication and Pregnancy KB

Topiramate (All indications) updated on 04-22-2025

Abruptio placentae (retroplacental hematoma)

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S8592 R28595	Cohen (Topiramate) (Controls exposed to Lamotrigine, sick) (Mixed indications), 2019	Placental abruption	early pregnancy	retrospective cohort (claims database)	exposed to other treatment, sick excluded	Adjustment: Yes	1.29 [0.72;2.31] excluded (control group)	54/2,280 50/2,682	104	2,280		ref
S8593 R28602	Cohen (Topiramate) (Controls unexposed NOS) (Mixed indications), 2019	Placental abruption	early pregnancy	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: Yes	1.27 [0.96;1.68]	54/2,280 20,269/1,440,631	20,323	2,280		ref
					Total	1 studies	1.27 [0.96;1.68]		20,323	2,280
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Topiramate) (Controls unexposed NOS) (Mixed indications;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 8592