Primidone AND Phenobarbital (Epilepsy) updated on 04-22-2025

Club foot / Talipes equinovarus

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S8671
R29207		 Bànhidy (Phenobarbital or Primidone), 2011 Clubfoot throughout pregnancy case control unexposed, sick Adjustment: No Matched 1.91 [0.03;109.96] C 1/7   0/10 1 7
ref
S8714
R29427		 Van der Pol (Phenobarbital) (Controls unexposed, disease free), 1991 Talipes throughout pregnancy prospective cohort unexposed, disease free excluded Adjustment: No Matched 4.74 [0.09;251.42] C
excluded (control group) 		0/12   0/55 0 12
ref
S8715
R29452		 Van der Pol (Phenobarbital) (Controls unexposed, sick), 1991 Talipes throughout pregnancy prospective cohort unexposed, sick Adjustment: No 1.87 [0.03;100.54] C 0/12   0/22 0 12
ref
Total 2 studies 1.89 [0.11;32.38] 1 19
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bànhidy (Phenobarbital or Primidone), 2011Bànhidy, 2011 1 1.91[0.03; 109.96]1749%ROB confusion: criticalROB selection: criticalROB classification: lowROB missing: lowROB mesure: moderateROB reporting: moderate Van der Pol (Phenobarbital) (Controls unexposed, sick), 1991Van der Pol, 1991 2 1.87[0.03; 100.54]01251%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.89[0.11; 32.38]1190.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Phenobarbital or Primidone; 2: Phenobarbital) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.87[0.03; 100.54]-12 -NAVan der Pol (Phenobarbital) (Controls unexposed, sick), 1991 1 case control studiescase control studies 1.91[0.03; 109.96]17 -NABànhidy (Phenobarbital or Primidone), 2011 1 Type of controls unexposed, sickunexposed, sick 1.89[0.11; 32.38]1190%NABànhidy (Phenobarbital or Primidone), 2011 Van der Pol (Phenobarbital) (Controls unexposed, sick), 1991 2 Tags Adjustment   - No  - No 1.89[0.11; 32.38]1190%NABànhidy (Phenobarbital or Primidone), 2011 Van der Pol (Phenobarbital) (Controls unexposed, sick), 1991 2 MatchedMatched 1.91[0.03; 109.96]17 -NABànhidy (Phenobarbital or Primidone), 2011 1 All studiesAll studies 1.89[0.11; 32.38]1190%NABànhidy (Phenobarbital or Primidone), 2011 Van der Pol (Phenobarbital) (Controls unexposed, sick), 1991 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 8714

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 4.74[0.09; 251.42]-12 -NAVan der Pol (Phenobarbital) (Controls unexposed, disease free), 1991 1 unexposed, sick controlsunexposed, sick controls 1.89[0.11; 32.38]1190%NABànhidy (Phenobarbital or Primidone), 2011 Van der Pol (Phenobarbital) (Controls unexposed, sick), 1991 20.510.01.0