Primidone AND Phenobarbital (Epilepsy) - Medication and Pregnancy KB

Primidone AND Phenobarbital (Epilepsy) updated on 04-22-2025

Neural Tube Defects

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S8694 R29315	Tomson (Phenobarbital or Primidone), 2018	Neural tube defects	at least 1st trimester	prospective cohort	exposed to other treatment, sick	Adjustment: No	17.21 [1.56;190.41] ^C	2/294 1/2,514	3	294		ref
S8656 R29148	Hernández-Díaz (Phenobarbital) (Controls exposed to Lamotrigine, sick), 2012	Neural tube defects	1st trimester	prospective cohort	exposed to other treatment, sick	Adjustment: No Controls: mixed indications	1.57 [0.08;32.85] ^C	0/199 2/1,562	2	199		ref
S8671 R29200	Bànhidy (Phenobarbital or Primidone), 2011	Neural tube defects	throughout pregnancy	case control	unexposed, sick	Adjustment: No Matched	1.46 [0.03;83.47] ^C	0/6 1/11	1	6		ref
S8673 R29215	Canger (Phenobarbital or Primidone), 1999	Neural tube defects	1st trimester	prospective cohort	unexposed, sick	Adjustment: No	0.21 [0.00;10.77] ^C	0/118 0/25	0	118		ref
					Total	4 studies	2.60 [0.40;17.05]		6	617
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Phenobarbital or Primidone; 2: Phenobarbital) (Controls exposed to Lamotrigine, sick; 3: Phenobarbital or Primidone; 4: Phenobarbital or Primidone;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Sub-groups analysis using all included studies

excluded