Primidone AND Phenobarbital (Epilepsy) updated on 04-22-2025

Neonatal intracranial hemorrhage

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S8648
R29031		 Burja (Phenobarbital or Primidone) (Controls unexposed, disease free), 2006 Intracranial hemorrhage during pregnancy (anytime or not specified) retrospective cohort (registry) unexposed, disease free excluded Adjustment: No 12.45 [0.45;341.34] C
excluded (control group) 		0/2   5/211 5 2
ref
S8649
R29036		 Burja (Phenobarbital or Primidone) (Controls unexposed, sick), 2006 Intracranial hemorrhage during pregnancy (anytime or not specified) retrospective cohort (registry) unexposed, sick Adjustment: No 3.93 [0.12;124.06] C 0/2   2/32 2 2
ref
S8650
R29062		 D'Souza (Phenobarbital) (Controls unexposed, disease free), 1991 Periventricular haemorrhage (germinal layer) throughout pregnancy prospective cohort unexposed, disease free excluded Adjustment: No Matched 17.57 [0.30;1024.08] C
excluded (control group) 		0/4   0/62 0 4
ref
S8651
R29091		 D'Souza (Phenobarbital) (Controls unexposed, sick), 1991 Periventricular haemorrhage (germinal layer) throughout pregnancy prospective cohort unexposed, sick Adjustment: No 2.14 [0.03;131.94] C 0/4   0/8 0 4
ref
Total 2 studies 3.06 [0.22;43.15] 2 6
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Burja (Phenobarbital or Primidone) (Controls unexposed, sick), 2006Burja, 2006 1 3.93[0.12; 124.06]2259%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA D'Souza (Phenobarbital) (Controls unexposed, sick), 1991D'Souza, 1991 2 2.14[0.03; 131.94]0441%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 3.06[0.22; 43.15]260.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Phenobarbital or Primidone) (Controls unexposed, sick; 2: Phenobarbital) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 3.06[0.22; 43.15]260%NABurja (Phenobarbital or Primidone) (Controls unexposed, sick), 2006 D'Souza (Phenobarbital) (Controls unexposed, sick), 1991 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 3.06[0.22; 43.15]260%NABurja (Phenobarbital or Primidone) (Controls unexposed, sick), 2006 D'Souza (Phenobarbital) (Controls unexposed, sick), 1991 2 Tags Adjustment   - No  - No 3.06[0.22; 43.15]260%NABurja (Phenobarbital or Primidone) (Controls unexposed, sick), 2006 D'Souza (Phenobarbital) (Controls unexposed, sick), 1991 2 All studiesAll studies 3.06[0.22; 43.15]260%NABurja (Phenobarbital or Primidone) (Controls unexposed, sick), 2006 D'Souza (Phenobarbital) (Controls unexposed, sick), 1991 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 8650, 8648

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale14.29[1.10; 186.14]560%NABurja (Phenobarbital or Primidone) (Controls unexposed, disease free), 2006 D'Souza (Phenobarbital) (Controls unexposed, disease free), 1991 2 unexposed, sick controlsunexposed, sick controls 3.06[0.22; 43.15]260%NABurja (Phenobarbital or Primidone) (Controls unexposed, sick), 2006 D'Souza (Phenobarbital) (Controls unexposed, sick), 1991 20.510.01.0