Primidone AND Phenobarbital (Epilepsy) updated on 04-22-2025

Eye defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S8652
R29111		 Dean (Phenobarbital or Primidone), 2002 Any eye disorder at least 1st trimester retrospective cohort unexposed, sick Adjustment: No 0.89 [0.29;2.73] C 9/63   6/38 15 63
ref
Total 1 studies 0.89 [0.29;2.73] 15 63
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Dean (Phenobarbital or Primidone), 2002Dean, 2002 1 0.89[0.29; 2.73]15630%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Phenobarbital or Primidone;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.89[0.29; 2.73]1563 -NADean (Phenobarbital or Primidone), 2002 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.89[0.29; 2.73]1563 -NADean (Phenobarbital or Primidone), 2002 1 Tags Adjustment   - No  - No 0.89[0.29; 2.73]1563 -NADean (Phenobarbital or Primidone), 2002 1 All studiesAll studies 0.89[0.29; 2.73]1563 -NADean (Phenobarbital or Primidone), 2002 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.89[0.29; 2.73]1563 -NADean (Phenobarbital or Primidone), 2002 10.510.01.0