Lamotrigine (All indications)

Caesarean

id	Study   Auto Artama (Lamotrigine) (Controls unexposed, disease free), 2013Artama (Lamotrigine) (Controls unexposed, sick), 2013Rihtman (Lamotrigine), 2013Borthen (Lamotrigine) (Controls unexposed, disease free), 2010Borthen (Lamotrigine) (Controls unexposed, sick), 2010	Lib. in paper	Exposition period  Auto during pregnancy (anytime or not specified)1st trimester2nd trimester3rd trimester2nd and/or 3rd trimesterthroughout pregnancyearly pregnancydays before deliverylate pregnancypreconception-onlypericonceptionalpreconceptional for kinetic reasonat least 1st trimester3 months (or more) before pregnancy or during pregnancy1st and 2nd trimester3 months or more before pregnancy or1st trimester	Study type  All studies Case control excluded Only case control	Control type    Auto unexposed (general population or NOS)unexposed, sickunexposed, disease freeexposed to other treatment, sicknot specifiedwhatever (meta-analysis)	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S8902 R30059	Artama (Lamotrigine) (Controls unexposed, disease free), 2013	Caesarean section	during pregnancy (anytime or not specified)	population based cohort retrospective	unexposed, disease free excluded	Adjustment: Yes	1.20 [0.81;1.77] excluded (control group)	32/173   114,791/721,948	114,823	173		ref
S8903 R30071	Artama (Lamotrigine) (Controls unexposed, sick), 2013	Caesarean section	during pregnancy (anytime or not specified)	population based cohort retrospective	unexposed, sick	Adjustment: Yes	0.93 [0.61;1.42]	32/173   331/1,800	363	173		ref
S8952 R30266	Rihtman (Lamotrigine), 2013	Cesarean section	at least 1st trimester excluded	prospective cohort	unexposed (general population or NOS)	Adjustment: No	2.07 [0.54;7.92] C excluded (exposition period)	6/40   4/51	10	40		ref
S8957 R30333	Borthen (Lamotrigine) (Controls unexposed, disease free), 2010	Caesarean	during pregnancy (anytime or not specified)	population based cohort retrospective	unexposed, disease free excluded	Adjustment: Yes	1.40 [1.00;1.90] excluded (control group)	44/233   51,806/362,302	51,850	233		ref
S8959 R30341	Borthen (Lamotrigine) (Controls unexposed, sick), 2010	Caesarean	during pregnancy (anytime or not specified)	population based cohort retrospective	unexposed, sick	Adjustment: No	1.05 [0.74;1.49] C	44/233   337/1,863	381	233		ref
					Total	2 studies	1.00 [0.77;1.31]		744	406
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

Sub-groups analysis using all included studies

excluded 8957, 8902