Lamotrigine (All indications) updated on 04-22-2025

Coarctation of aorta

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S10035
R36158		 Blotière (Lamotrigine) (Mixed indications), 2019 Coarctation of aorta 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No 2.40 [0.50;7.10] 3/2,997   779/1,875,733 782 2,997
ref
Total 1 studies 2.40 [0.64;9.04] 782 2,997
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Blotière (Lamotrigine) (Mixed indications), 2019Blotière, 2019 1 2.40[0.50; 7.10]7822,9970%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.95.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Lamotrigine) (Mixed indications;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.40[0.64; 9.04]7822,997 -NABlotière (Lamotrigine) (Mixed indications), 2019 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.40[0.64; 9.04]7822,997 -NABlotière (Lamotrigine) (Mixed indications), 2019 1 Tags Adjustment   - No  - No 2.40[0.64; 9.04]7822,997 -NABlotière (Lamotrigine) (Mixed indications), 2019 1 All studiesAll studies 2.40[0.64; 9.04]7822,997 -NABlotière (Lamotrigine) (Mixed indications), 2019 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.40[0.64; 9.04]7822,997 -NABlotière (Lamotrigine) (Mixed indications), 2019 10.510.01.0