Lamotrigine (All indications) updated on 04-22-2025

Abruptio placentae (retroplacental hematoma)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S8963
R30353		 Cohen (Lamotrigine) (Mixed indications), 2019 Placental abruption early pregnancy retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 1.15 [0.85;1.56] 50/2,682   20,269/1,440,631 20,319 2,682
ref
Total 1 studies 1.15 [0.85;1.56] 20,319 2,682
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Cohen (Lamotrigine) (Mixed indications), 2019Cohen, 2019 1 1.15[0.85; 1.56]20,3192,6820%ROB confusion: moderateROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Lamotrigine) (Mixed indications;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.15[0.85; 1.56]20,3192,682 -NACohen (Lamotrigine) (Mixed indications), 2019 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.15[0.85; 1.56]20,3192,682 -NACohen (Lamotrigine) (Mixed indications), 2019 1 Tags Adjustment   - Yes  - Yes 1.15[0.85; 1.56]20,3192,682 -NACohen (Lamotrigine) (Mixed indications), 2019 1 All studiesAll studies 1.15[0.85; 1.56]20,3192,682 -NACohen (Lamotrigine) (Mixed indications), 2019 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.15[0.85; 1.56]20,3192,682 -NACohen (Lamotrigine) (Mixed indications), 2019 10.510.01.0