Lamotrigine (All indications)

Severe cognitive developmental delay (Mental retardation) (3-6 years old)

id	Study   Auto Coste (Lamotrigine) (Controls unexposed NOS) (Mixed indications), 2020Cummings (Lamotrigine), 2011	Lib. in paper	Exposition period  Auto during pregnancy (anytime or not specified)1st trimester2nd trimester3rd trimester2nd and/or 3rd trimesterthroughout pregnancyearly pregnancydays before deliverylate pregnancypreconception-onlypericonceptionalpreconceptional for kinetic reasonat least 1st trimester3 months (or more) before pregnancy or during pregnancy1st and 2nd trimester3 months or more before pregnancy or1st trimester	Study type  All studies Case control excluded Only case control	Control type    Auto unexposed (general population or NOS)unexposed, sickunexposed, disease freeexposed to other treatment, sicknot specifiedwhatever (meta-analysis)	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S8978 R30438	Coste (Lamotrigine) (Controls unexposed NOS) (Mixed indications), 2020	Diagnosis Mental retardation (F70–F79) (mean age of 3.6 years old)	during pregnancy (anytime or not specified)	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: Yes	2.40 [1.40;4.00]	15/2,813   3,385/1,707,707	3,400	2,813		ref
S8942 R30235	Cummings (Lamotrigine), 2011	Significant delay (score ≥2 SD below the mean) (Bayley Scales of Infant Development or the Griffiths Scale) (mean age in years: m1=2.7 and m0=4.3)	throughout pregnancy	retrospective cohort (registry)	unexposed, disease free	Adjustment: No	0.41 [0.02;10.40] C	0/35   1/44	1	35		ref
					Total	2 studies	2.10 [0.84;5.24]		3,401	2,848
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

Sub-groups analysis using all included studies

excluded