| id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| S16195 R69668 |
Hernandez-Diaz (Lamotrigine) (Epilepsy), 2024 | Autism spectrum disorder (ASD) - At least two visits with codes for ASD - Median follow-up was 2 years | 2nd and/or 3rd trimester | retrospective cohort (claims database) | unexposed, sick | Adjustment: Yes | 0.93 [0.60;1.44] | 32/3,134 102/8,815 | 134 | 3,134 |
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| S17412 R73052 |
Madley-Dowd_SE (Lamotrigine) (Controls unexposed, general pop) (Mixed indications), 2024 | Autism - ICD-8/9/10 codes - Mean 5-20 years old (according groups) | during pregnancy (anytime or not specified) | population based cohort retrospective | unexposed (general population or NOS) | Adjustment: Yes Partial overlapping | 0.83 [0.69;0.99] | 134/5,035 68,788/2,651,210 | 68,922 | 5,035 |
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| S17413 R73058 |
Madley-Dowd_SE (Lamotrigine) (Controls unexposed, sibling) (Mixed indications), 2024 | Autism - ICD-8/9/10 codes - Mean 5-20 years old (according groups) | during pregnancy (anytime or not specified) | population based cohort retrospective | sibling excluded | Adjustment: Yes Partial overlapping |
0.76 [0.50;1.16] excluded (control group) |
-/- -/- | - | - |
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| S17266 R72387 |
Madley-Dowd_UK (Lamotrigine) (Controls unexposed, general pop) (Mixed indications), 2024 | Autism - ICD10 codes - Median 6.18 (3.53-9.94) years old | during pregnancy (anytime or not specified) | retrospective cohort (claims database) | unexposed (general population or NOS) | Adjustment: Yes | 1.10 [0.67;1.78] | 20/939 7,657/514,066 | 7,677 | 939 |
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| S17274 R72388 |
Madley-Dowd_UK (Lamotrigine) (Controls unexposed, sibling) (Mixed indications), 2024 | Autism - ICD10 codes - Median 6.18 (3.53-9.94) years old | during pregnancy (anytime or not specified) | retrospective cohort (claims database) | sibling excluded | Adjustment: Yes |
1.21 [0.55;2.68] excluded (control group) |
-/- -/- | - | - |
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| S12727 R48014 |
Bjørk (Lamotrigine) (Controls unexposed NOS) (Mixed indications), 2022 | Diagnosis of childhood autism (F84.0), atypical autism (F84.1), and Asperger syndrome (F84.5) - Median follow up lamotrigine 5.1 (2.4-8.5) years old | during pregnancy (anytime or not specified) | population based cohort retrospective | unexposed (general population or NOS) excluded | Adjustment: Yes |
1.13 [0.91;1.40] excluded (control group) |
82/7,950 38,437/4,463,879 | 38,519 | 7,950 |
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| S12728 R48015 |
Bjørk (Lamotrigine) (Controls unexposed, sick) (Mixed indications), 2022 | Diagnosis of childhood autism (F84.0), atypical autism (F84.1), and Asperger syndrome (F84.5) - Median follow up lamotrigine 5.1 (2.4-8.5) years old | during pregnancy (anytime or not specified) | population based cohort retrospective | unexposed, sick | Adjustment: No Controls: epilepsy indication | 0.83 [0.65;1.07] C | 82/7,950 267/21,634 | 349 | 7,950 |
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| S8978 R39746 |
Coste (Lamotrigine) (Controls unexposed NOS) (Mixed indications), 2020 | Diagnosis Pervasive developmental disorders (F84) (mean age of 3.6 years old) | during pregnancy (anytime or not specified) | retrospective cohort (claims database) | unexposed (general population or NOS) | Adjustment: Yes | 1.30 [0.70;2.40] | 10/2,813 4,254/1,707,707 | 4,264 | 2,813 |
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| S9931 R39727 |
Bjørk (Lamotrigine) (Controls unexposed, disease free), 2018 | Autistic traits at 18 months and/or at 36 months (M-CHAT <2/6 critical or <3/23 or SCQ >13) | during pregnancy (anytime or not specified) | population based cohort propective | unexposed, disease free excluded | Adjustment: No |
2.05 [1.13;3.72] C excluded (control group) |
13/76 6,907/75,497 | 6,920 | 76 |
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| S9973 R39726 |
Bjørk (Lamotrigine) (Controls unexposed, sick), 2018 | Autistic traits at 18 months and/or at 36 months (M-CHAT <2/6 critical or <3/23 or SCQ >13) | during pregnancy (anytime or not specified) | population based cohort propective | unexposed, sick | Adjustment: No | 1.87 [0.91;3.84] C | 13/76 27/272 | 40 | 76 |
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| S8941 R39754 |
Cohen-Israel (Lamotrigine), 2018 | Autism - Medical files and by a telephone interview using an ad-hoc questionnaire - A majority between 6-12 years old | 1st trimester | retrospective cohort | unexposed, disease free | Adjustment: No Matched | 0.33 [0.01;8.20] C | 0/83 1/83 | 1 | 83 |
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| S8933 R39739 |
Bromley (Lamotrigine) (Controls unexposed, disease free), 2013 | Autistic Spectrum Disorders (at 6 years old) | during pregnancy (anytime or not specified) | prospective cohort | unexposed, disease free excluded | Adjustment: No |
1.81 [0.20;16.76] C excluded (control group) |
1/30 4/214 | 5 | 30 |
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| S8936 R39743 |
Bromley (Lamotrigine) (Controls unexposed, sick), 2013 | Autistic Spectrum Disorders (at 6 years old) | during pregnancy (anytime or not specified) | prospective cohort | unexposed, sick | Adjustment: No | 2.68 [0.10;68.88] C | 1/30 0/26 | 1 | 30 |
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| Total | 8 studies | 0.92 [0.79;1.07] | 81,388 | 20,060 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1: Lamotrigine) (Epilepsy; 2: Lamotrigine) (Controls unexposed, general pop) (Mixed indications; 3: Lamotrigine) (Controls unexposed, general pop) (Mixed indications; 4: Lamotrigine) (Controls unexposed, sick) (Mixed indications; 5: Lamotrigine) (Controls unexposed NOS) (Mixed indications; 6: Lamotrigine) (Controls unexposed, sick; 7: Lamotrigine; 8: Lamotrigine) (Controls unexposed, sick;
Asymetry test p-value = 0.1250 (by Egger's regression)
slope=-0.2518 (0.1001); intercept=0.9652 (0.5417); t=1.7820; p=0.1250
excluded 8933, 9931, 12727, 17413, 17274