Lamotrigine (All indications) updated on 04-22-2025

Respiratory system anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17498
R73509		 Wiggs (Epilepsy) (Lamotrigine), 2024 Respiratory system malformations early pregnancy population based cohort retrospective unexposed, sick Adjustment: Yes 0.85 [0.35;2.08] -/1,412   -/9,364 - 1,412
ref
Total 1 studies 0.85 [0.35;2.07] 0 1,412
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Wiggs (Epilepsy) (Lamotrigine), 2024Wiggs, 2024 1 0.85[0.35; 2.08]-1,4120%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Epilepsy) (Lamotrigine;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.85[0.35; 2.07]-1,412 -NAWiggs (Epilepsy) (Lamotrigine), 2024 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.85[0.35; 2.07]-1,412 -NAWiggs (Epilepsy) (Lamotrigine), 2024 1 Tags Adjustment   - Yes  - Yes 0.85[0.35; 2.07]-1,412 -NAWiggs (Epilepsy) (Lamotrigine), 2024 1 All studiesAll studies 0.85[0.35; 2.07]-1,412 -NAWiggs (Epilepsy) (Lamotrigine), 2024 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.85[0.35; 2.07]-1,412 -NAWiggs (Epilepsy) (Lamotrigine), 2024 10.510.01.0