Lamotrigine (All indications) updated on 04-22-2025

Genital anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17498
R73512		 Wiggs (Epilepsy) (Lamotrigine), 2024 Genital organ malformations early pregnancy population based cohort retrospective unexposed, sick Adjustment: Yes 0.76 [0.44;1.32] -/1,412   -/9,364 - 1,412
ref
S8969
R30376		 Ban (Lamotrigine) (Mixed indications), 2015 Genital system anomaly 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No 0.92 [0.13;6.56] C 1/273   1,023/257,153 1,024 273
ref
Total 2 studies 0.77 [0.45;1.31] 1,024 1,685
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Wiggs (Epilepsy) (Lamotrigine), 2024Wiggs, 2024 1 0.76[0.44; 1.32]-1,41293%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Ban (Lamotrigine) (Mixed indications), 2015Ban, 2015 2 0.92[0.13; 6.56]1,0242737%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 0.77[0.45; 1.31]1,0241,6850.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Epilepsy) (Lamotrigine; 2: Lamotrigine) (Mixed indications;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.77[0.45; 1.31]1,0241,6850%NAWiggs (Epilepsy) (Lamotrigine), 2024 Ban (Lamotrigine) (Mixed indications), 2015 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.92[0.13; 6.56]1,024273 -NABan (Lamotrigine) (Mixed indications), 2015 1 unexposed, sickunexposed, sick 0.76[0.44; 1.32]-1,412 -NAWiggs (Epilepsy) (Lamotrigine), 2024 1 Tags Adjustment   - No  - No 0.92[0.13; 6.56]1,024273 -NABan (Lamotrigine) (Mixed indications), 2015 1   - Yes  - Yes 0.76[0.44; 1.32]-1,412 -NAWiggs (Epilepsy) (Lamotrigine), 2024 1 All studiesAll studies 0.77[0.45; 1.31]1,0241,6850%NAWiggs (Epilepsy) (Lamotrigine), 2024 Ban (Lamotrigine) (Mixed indications), 2015 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.92[0.13; 6.56]1,024273 -NABan (Lamotrigine) (Mixed indications), 2015 1 unexposed, sick controlsunexposed, sick controls 0.76[0.44; 1.32]-1,412 -NAWiggs (Epilepsy) (Lamotrigine), 2024 10.510.01.0