Lamotrigine (All indications) updated on 04-22-2025

Therapeutic terminations of pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S8913
R30125		 Miškov (Lamotrigine) (Controls unexposed, disease free), 2016 Medically induced abortion during pregnancy (anytime or not specified) prospective cohort unexposed, disease free excluded Adjustment: No 3.49 [0.07;179.12] C
excluded (control group) 		0/37   0/128 0 37
ref
S8914
R30131		 Miškov (Lamotrigine) (Controls unexposed, sick), 2016 Medically induced abortion during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No 0.10 [0.00;5.62] C 0/37   0/4 0 37
ref
Total 1 studies 0.10 [0.00;5.62] 0 37
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Miškov (Lamotrigine) (Controls unexposed, sick), 2016Miškov, 2016 1 0.10[0.00; 5.62]0370%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: criticalROB mesure: moderateROB reporting: moderate0.02.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Lamotrigine) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.10[0.00; 5.62]-37 -NAMiškov (Lamotrigine) (Controls unexposed, sick), 2016 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.10[0.00; 5.62]-37 -NAMiškov (Lamotrigine) (Controls unexposed, sick), 2016 1 Tags Adjustment   - No  - No 0.10[0.00; 5.62]-37 -NAMiškov (Lamotrigine) (Controls unexposed, sick), 2016 1 All studiesAll studies 0.10[0.00; 5.62]-37 -NAMiškov (Lamotrigine) (Controls unexposed, sick), 2016 10.010.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 8913

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 3.49[0.07; 179.12]-37 -NAMiškov (Lamotrigine) (Controls unexposed, disease free), 2016 1 unexposed, sick controlsunexposed, sick controls Out of scale0.10[0.00; 5.62]-37 -NAMiškov (Lamotrigine) (Controls unexposed, sick), 2016 10.510.01.0