| id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| S17414 R73068 |
Madley-Dowd_SE (Levetiracetam) (Controls exposed to LTG) (Mixed indications), 2024 | Autism - ICD-8/9/10 codes - Mean 5-20 years old (according groups) | during pregnancy (anytime or not specified) | population based cohort retrospective | exposed to other treatment, sick excluded | Adjustment: Yes Partial overlapping |
0.97 [0.47;1.99] excluded (control group) |
8/613 134/5,035 | 142 | 613 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S17415 R73072 |
Madley-Dowd_SE (Levetiracetam) (Controls unexposed, general pop) (Mixed indications), 2024 | Autism - ICD-8/9/10 codes - Mean 5-20 years old (according groups) | during pregnancy (anytime or not specified) | population based cohort retrospective | unexposed (general population or NOS) | Adjustment: Yes Partial overlapping | 0.80 [0.40;1.62] | 8/613 68,788/2,651,210 | 68,796 | 613 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S17416 R73076 |
Madley-Dowd_SE (Levetiracetam) (Controls unexposed, sibling) (Mixed indications), 2024 | Autism - ICD-8/9/10 codes - Mean 5-20 years old (according groups) | during pregnancy (anytime or not specified) | population based cohort retrospective | sibling excluded | Adjustment: Yes Partial overlapping |
0.50 [0.10;2.62] excluded (control group) |
-/- -/- | - | - |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S17282 R72331 |
Madley-Dowd_UK (Levetiracetam) (Controls exposed to LTG) (Mixed indications), 2024 | Autism - ICD10 codes - Median 4.19 (2.56-6.79) years old | during pregnancy (anytime or not specified) | retrospective cohort (claims database) | exposed to other treatment, sick excluded | Adjustment: Yes |
0.82 [0.20;3.34] excluded (control group) |
-/193 20/939 | - | 193 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S17267 R72285 |
Madley-Dowd_UK (Levetiracetam) (Controls unexposed, general pop) (Mixed indications), 2024 | Autism - ICD10 codes - Median 4.19 (2.56-6.79) years old | during pregnancy (anytime or not specified) | retrospective cohort (claims database) | unexposed (general population or NOS) | Adjustment: Yes | 0.90 [0.22;3.67] | -/193 7,657/514,066 | - | 193 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S17275 R72309 |
Madley-Dowd_UK (Levetiracetam) (Controls unexposed, sibling) (Mixed indications), 2024 | Autism - ICD10 codes - Median 4.19 (2.56-6.79) years old | during pregnancy (anytime or not specified) | retrospective cohort (claims database) | sibling excluded | Adjustment: Yes |
0.59 [0.12;3.01] excluded (control group) |
-/- -/- | - | - |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S12775 R48182 |
Bjørk (Levetiracetam) (Controls exposed to Lamotrigine, sick), 2022 | Diagnosis of childhood autism (F84.0), atypical autism (F84.1), and Asperger syndrome (F84.5) - Median follow up levetiracetam 3.6 (1.8-6.5) years old | during pregnancy (anytime or not specified) | population based cohort retrospective | exposed to other treatment, sick excluded | Adjustment: No |
0.71 [0.32;1.57] C excluded (control group) |
7/1,017 49/5,073 | 56 | 1,017 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S12776 R48184 |
Bjørk (Levetiracetam) (Controls unexposed NOS), 2022 | Diagnosis of childhood autism (F84.0), atypical autism (F84.1), and Asperger syndrome (F84.5) - Median follow up levetiracetam 3.6 (1.8-6.5) years old | during pregnancy (anytime or not specified) | population based cohort retrospective | unexposed (general population or NOS) excluded | Adjustment: Yes |
1.59 [0.76;3.33] excluded (control group) |
7/1,017 38,437/4,463,879 | 38,444 | 1,017 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S12777 R48186 |
Bjørk (Levetiracetam) (Controls unexposed, sick), 2022 | Diagnosis of childhood autism (F84.0), atypical autism (F84.1), and Asperger syndrome (F84.5) - Median follow up levetiracetam 3.6 (1.8-6.5) years old | during pregnancy (anytime or not specified) | population based cohort retrospective | unexposed, sick | Adjustment: Yes | 1.06 [0.49;2.30] | 7/1,004 267/21,634 | 274 | 1,004 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S10071 R36655 |
Coste (Levetiracetam) (Controls exposed to Lamotrigine, sick), 2020 | Diagnosis Pervasive developmental disorders (F84) (mean age of 3.7 years old) | during pregnancy (anytime or not specified) | retrospective cohort (claims database) | exposed to other treatment, sick excluded | Adjustment: Yes |
1.80 [0.50;6.60] excluded (control group) |
4/621 7/2,108 | 11 | 621 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S9020 R30714 |
Coste (Levetiracetam) (Controls unexposed, NOS), 2020 | Diagnosis Pervasive developmental disorders (F84) (mean age of 3.6 years old) | during pregnancy (anytime or not specified) | retrospective cohort (claims database) | unexposed (general population or NOS) | Adjustment: Yes | 2.50 [0.90;6.60] | 4/621 4,280/1,710,441 | 4,284 | 621 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S9022 R30740 |
Huber-Mollema (Levetiracetam), 2019 | Diagnosis of autism spectrum disorder | throughout pregnancy | prospective cohort | exposed to other treatment, sick | Adjustment: No | 0.72 [0.08;6.75] C | 1/30 4/88 | 5 | 30 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Total | 5 studies | 1.09 [0.71;1.67] | 73,359 | 2,461 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1: Levetiracetam) (Controls unexposed, general pop) (Mixed indications; 2: Levetiracetam) (Controls unexposed, general pop) (Mixed indications; 3: Levetiracetam) (Controls unexposed, sick; 4: Levetiracetam) (Controls unexposed, NOS; 5: Levetiracetam;
Asymetry test p-value = 0.9076 (by Egger's regression)
slope=0.0005 (0.6902); intercept=0.1779 (1.4098); t=0.1262; p=0.9076
excluded 10071, 12775, 12776, 17414, 17416, 17282, 17275