Oxcarbazepine (All indications) updated on 04-22-2025

Cognitive developmental disorders/delay (> 6 years old)

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S12731
R53721
Bjørk (Oxcarbazepine) (Controls exposed to Lamotrigine, sick), 2022 Diagnosis of intellectual disability (ID): mild ID (F70), moderate ID (F71), severe ID (F72), and profound ID (F73) - Median follow up oxcarbazepine 10.5 (5.5-15.5) years old during pregnancy (anytime or not specified) population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 2.53 [1.32;4.86] C
excluded (control group)
16/1,539   21/5,073 37 1,539
ref
S12733
R53722
Bjørk (Oxcarbazepine) (Controls unexposed NOS), 2022 Diagnosis of intellectual disability (ID): mild ID (F70), moderate ID (F71), severe ID (F72), and profound ID (F73) - Median follow up oxcarbazepine 10.5 (5.5-15.5) years old during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) excluded Adjustment: Yes 1.95 [1.19;3.18]
excluded (control group)
16/1,539   16,384/4,463,879 16,400 1,539
ref
S12732
R53723
Bjørk (Oxcarbazepine) (Controls unexposed, sick), 2022 Diagnosis of intellectual disability (ID): mild ID (F70), moderate ID (F71), severe ID (F72), and profound ID (F73) - Median follow up oxcarbazepine 10.5 (5.5-15.5) years old during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: Yes 0.87 [0.48;1.58] -/1,429   139/21,634 - 1,429
ref
Total 1 studies 0.87 [0.48;1.58] 0 1,429
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bjørk (Oxcarbazepine) (Controls unexposed, sick), 2022Bjørk, 2022 1 0.87[0.48; 1.58]-1,4290%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Oxcarbazepine) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.87[0.48; 1.58]-1,429 -NABjørk (Oxcarbazepine) (Controls unexposed, sick), 2022 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.87[0.48; 1.58]-1,429 -NABjørk (Oxcarbazepine) (Controls unexposed, sick), 2022 1 Tags Adjustment   - Yes  - Yes 0.87[0.48; 1.58]-1,429 -NABjørk (Oxcarbazepine) (Controls unexposed, sick), 2022 1 All studiesAll studies 0.87[0.48; 1.58]-1,429 -NABjørk (Oxcarbazepine) (Controls unexposed, sick), 2022 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 12731, 12733

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.95[1.19; 3.19]16,4001,539 -NABjørk (Oxcarbazepine) (Controls unexposed NOS), 2022 1 unexposed, sick controlsunexposed, sick controls 0.87[0.48; 1.58]1301,429 -NABjørk (Oxcarbazepine) (Controls unexposed, sick), 2022 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 2.53[1.32; 4.86]371,539 -NABjørk (Oxcarbazepine) (Controls exposed to Lamotrigine, sick), 2022 10.510.01.0