Phenobarbital (All indications) updated on 04-22-2025

Hearing loss / Auditory deficit

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S9179
R31643		 Shankaran (Phenobarbital) (Other indications), 2002 Hearing impairment days before delivery randomized controlled trial unexposed, sick Adjustment: Randomisation 0.88 [0.30;2.54] C 7/224   7/197 14 224
ref
Total 1 studies 0.88 [0.30;2.54] 14 224
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Shankaran (Phenobarbital) (Other indications), 2002Shankaran, 2002 1 0.88[0.30; 2.54]142240%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Phenobarbital) (Other indications;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0 RCTRCT 0.88[0.30; 2.54]14224 -NAShankaran (Phenobarbital) (Other indications), 2002 1 Type of controls unexposed, sickunexposed, sick 0.88[0.30; 2.54]14224 -NAShankaran (Phenobarbital) (Other indications), 2002 1 Tags Adjustment   - Randomisation  - Randomisation 0.88[0.30; 2.54]14224 -NAShankaran (Phenobarbital) (Other indications), 2002 1 All studiesAll studies 0.88[0.30; 2.54]14224 -NAShankaran (Phenobarbital) (Other indications), 2002 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.88[0.30; 2.54]14224 -NAShankaran (Phenobarbital) (Other indications), 2002 10.510.01.0