Phenobarbital (All indications) updated on 04-22-2025

Cerebral palsy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S9179
R31641		 Shankaran (Phenobarbital) (Other indications), 2002 Cerebral palsy (CP) (included diplegia, hemiplegia, triplegia, or quadriplegia) days before delivery excluded randomized controlled trial unexposed, sick Adjustment: Randomisation 0.73 [0.38;1.42] C
excluded (exposition period) 		18/224   21/197 39 224
ref
S9172
R31554		 Van der Pol (Phenobarbital) (Controls unexposed, disease free), 1991 Abnormal neurologic examination (neurologic handicap) throughout pregnancy prospective cohort unexposed, disease free excluded Adjustment: No Matched 1.55 [0.06;40.54] C
excluded (control group) 		0/12   1/55 1 12
ref
S9173
R31579		 Van der Pol (Phenobarbital) (Controls unexposed, sick), 1991 Abnormal neurologic examination (neurologic handicap) throughout pregnancy prospective cohort unexposed, sick Adjustment: No 1.87 [0.03;100.54] C 0/12   0/22 0 12
ref
Total 1 studies 1.87 [0.03;100.54] 0 12
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Van der Pol (Phenobarbital) (Controls unexposed, sick), 1991Van der Pol, 1991 1 1.87[0.03; 100.54]0120%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Phenobarbital) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.87[0.03; 100.54]-12 -NAVan der Pol (Phenobarbital) (Controls unexposed, sick), 1991 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.87[0.03; 100.54]-12 -NAVan der Pol (Phenobarbital) (Controls unexposed, sick), 1991 1 Tags Adjustment   - No  - No 1.87[0.03; 100.54]-12 -NAVan der Pol (Phenobarbital) (Controls unexposed, sick), 1991 1 All studiesAll studies 1.87[0.03; 100.54]-12 -NAVan der Pol (Phenobarbital) (Controls unexposed, sick), 1991 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 9172

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.55[0.06; 40.54]112 -NAVan der Pol (Phenobarbital) (Controls unexposed, disease free), 1991 1 unexposed, sick controlsunexposed, sick controls 1.87[0.03; 100.54]-12 -NAVan der Pol (Phenobarbital) (Controls unexposed, sick), 1991 10.510.01.0