Phenytoin (All indications)

Psychomotor developmental disorders/delay

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S9259
R32101		 Cohen (Phenytoin), 2011 Motor Index score (the Bayley Scales of Infant Development (BSID-II)) during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick Adjustment: Yes extrapolated (cont. endpoint) 0.60 [0.28;1.31] -/32   -/62 - 32
ref
S9268
R32146		 Thomas b (Phenytoin), 2008 Impaired Motor Development Quotient < 84 (The Developmental Assessment Scale (DAS II)) during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No 0.53 [0.16;1.83] C 5/29   9/32 14 29
ref
S9263
R32123		 Koch (Phenytoin), 1996 Minor neurological dysfunction (at age 6) (Touwen) during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: No Matched 0.83 [0.08;8.43] C 1/10   4/34 5 10
ref
Total 3 studies 0.60 [0.32;1.12] 19 71
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Cohen (Phenytoin), 2011Cohen, 2011 1 0.60[0.28; 1.31]-3267%ROB confusion: moderateROB selection: lowROB classification: lowROB missing: criticalROB mesure: lowROB reporting: moderate Thomas b (Phenytoin), 2008Thomas b, 2008 2 0.53[0.16; 1.83]142926%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: criticalROB mesure: lowROB reporting: moderate Koch (Phenytoin), 1996Koch, 1996 3 0.83[0.08; 8.43]5107%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (3 studies) I2 = 0% 0.60[0.32; 1.12]19710.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Phenytoin; 2: Phenytoin; 3: Phenytoin;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.60[0.32; 1.12]19710%NACohen (Phenytoin), 2011 Thomas b (Phenytoin), 2008 Koch (Phenytoin), 1996 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.83[0.08; 8.43]510 -NAKoch (Phenytoin), 1996 1 unexposed, sickunexposed, sick 0.53[0.16; 1.83]1429 -NAThomas b (Phenytoin), 2008 1 exposed to other treatment, sickexposed to other treatment, sick 0.60[0.28; 1.30]-32 -NACohen (Phenytoin), 2011 1 Tags Adjustment   - No  - No 0.59[0.20; 1.75]19390%NAThomas b (Phenytoin), 2008 Koch (Phenytoin), 1996 2   - Yes  - Yes 0.60[0.28; 1.30]-32 -NACohen (Phenytoin), 2011 1 extrapolated (cont. endpoint)extrapolated (cont. endpoint) 0.60[0.28; 1.30]-32 -NACohen (Phenytoin), 2011 1 MatchedMatched 0.83[0.08; 8.43]510 -NAKoch (Phenytoin), 1996 1 All studiesAll studies 0.60[0.32; 1.12]19710%NACohen (Phenytoin), 2011 Thomas b (Phenytoin), 2008 Koch (Phenytoin), 1996 30.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.83[0.08; 8.43]510 -NAKoch (Phenytoin), 1996 1 unexposed, sick controlsunexposed, sick controls 0.53[0.16; 1.83]1429 -NAThomas b (Phenytoin), 2008 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.60[0.28; 1.30]-32 -NACohen (Phenytoin), 2011 10.510.01.0